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Literature DB >> 23748883

Isolation of fucoxanthin and highly unsaturated monogalactosyldiacylglycerol from brown alga Fucus evanescens C Agardh and in vitro investigation of their antitumor activity.

Tatiana I Imbs¹, Svetlana P Ermakova, Sergey A Fedoreyev, Stanislav D Anastyuk, Tatiana N Zvyagintseva.

Abstract

Fucoxanthin (FX) and highly unsaturated monogalactosyldiacylglycerol (MGDG) were isolated from the ethanol extract of brown alga Fucus evanescens. Their structures were identified by nuclear magnetic resonance, complemented by electrospray ionization mass spectrometry (ESIMS). MGDG was identified as 1-O-(5Z,8Z,11Z,14Z,17Z-eicosapentanoyl)-2-O-(6Z,9Z,12Z,15Z-octadecatetraenoyl)-3-O-β-D-galactopiranosyl-sn-glycerol. Antitumor activity of these compounds was tested on human melanoma (SK-MEL-28) cells. MGDG and FX inhibited the growth of human melanoma cells in a dose-dependent manner. IC50 values for growth inhibition were 104 and 114 μM, correspondently.

Entities: Chemical Disease Species

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Year: 2013 PMID： 23748883 DOI： 10.1007/s10126-013-9507-2

Source DB: PubMed Journal: Mar Biotechnol (NY) ISSN： 1436-2228 Impact factor: 3.619

16 in total

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Journal: Glycobiology Date: 2006-06-24 Impact factor: 4.313

3. Selective in vivo anti-inflammatory action of the galactolipid monogalactosyldiacylglycerol.

Authors: Annalisa Bruno; Cosmo Rossi; Gabriele Marcolongo; Annalisa Di Lena; Alfonso Venzo; Christopher P Berrie; Daniela Corda
Journal: Eur J Pharmacol Date: 2005-10-25 Impact factor: 4.432

4. Two new monogalactosyl diacylglycerols from brown alga Sargassum thunbergii.

Authors: Young Hwan Kim; Eun-Hee Kim; Chulhyun Lee; Mi-Hee Kim; Jung-Rae Rho
Journal: Lipids Date: 2007-03-07 Impact factor: 1.880

5. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells.

Authors: Masashi Hosokawa; Masahiro Kudo; Hayato Maeda; Hiroyuki Kohno; Takuji Tanaka; Kazuo Miyashita
Journal: Biochim Biophys Acta Date: 2004-11-18

6. A new solution for an old problem: the regiochemical distribution of the acyl chains in galactolipids can be established by electrospray ionization tandem mass spectrometry.

Authors: Graziano Guella; Rita Frassanito; Ines Mancini
Journal: Rapid Commun Mass Spectrom Date: 2003 Impact factor: 2.419

7. Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites.

Authors: Nakkarike M Sachindra; Emiko Sato; Hayato Maeda; Masashi Hosokawa; Yoshimi Niwano; Masahiro Kohno; Kazuo Miyashita
Journal: J Agric Food Chem Date: 2007-09-26 Impact factor: 5.279

8. Sensitization of human malignant lymphoid cells to etoposide by fucoidan, a brown seaweed polysaccharide.

Authors: A Philchenkov; M Zavelevich; T Imbs; T Zvyagintseva; T Zaporozhets
Journal: Exp Oncol Date: 2007-09

9. Structure of digalactosyldiacylglycerol from oats.

Authors: J B Hauksson; M H Bergqvist; L Rilfors
Journal: Chem Phys Lipids Date: 1995-10-22 Impact factor: 3.329

10. In vitro anti-inflammatory and anti-proliferative activity of sulfolipids from the red alga Porphyridium cruentum.

Authors: J P Bergé; E Debiton; J Dumay; P Durand; C Barthomeuf
Journal: J Agric Food Chem Date: 2002-10-09 Impact factor: 5.279

8 in total

1. Anticancer effects of fucoxanthin and fucoxanthinol on colorectal cancer cell lines and colorectal cancer tissues.

Authors: Kazuto Takahashi; Masashi Hosokawa; Hiroyuki Kasajima; Kazuteru Hatanaka; Kazuhiro Kudo; Norihiko Shimoyama; Kazuo Miyashita
Journal: Oncol Lett Date: 2015-06-16 Impact factor: 2.967

2. Bioprospecting of Less-Polar Constituents from Endemic Brown Macroalga Fucus virsoides J. Agardh from the Adriatic Sea and Targeted Antioxidant Effects In Vitro and In Vivo (Zebrafish Model).

Authors: Igor Jerković; Ana-Marija Cikoš; Sanja Babić; Lara Čižmek; Krunoslav Bojanić; Krunoslav Aladić; Nikolay V Ul'yanovskii; Dmitry S Kosyakov; Albert T Lebedev; Rozelindra Čož-Rakovac; Polonca Trebše; Stela Jokić
Journal: Mar Drugs Date: 2021-04-22 Impact factor: 5.118

Review 3. Glycolipids from seaweeds and their potential biotechnological applications.

Authors: Erwan Plouguerné; Bernardo A P da Gama; Renato C Pereira; Eliana Barreto-Bergter
Journal: Front Cell Infect Microbiol Date: 2014-12-17 Impact factor: 5.293

4. Melanoma and brown seaweed: an integrative hypothesis.

Authors: Jane Teas; Mohammad R Irhimeh
Journal: J Appl Phycol Date: 2016-10-11 Impact factor: 3.215

Review 5. Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy.

Authors: Sarah Méresse; Mostefa Fodil; Fabrice Fleury; Benoît Chénais
Journal: Int J Mol Sci Date: 2020-12-04 Impact factor: 5.923