Literature DB >> 23748773

Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside.

Manami Kurisu1, Yusaku Miyamae, Kazuma Murakami, Junkyu Han, Hiroko Isoda, Kazuhiro Irie, Hideyuki Shigemori.   

Abstract

We examined the effects of acteoside (1a), which was isolated from Orobanche minor, and its derivatives on the aggregation of a 42-mer amyloid β protein (Aβ42) in our search for anti-amyloidogenic compounds for Alzheimer's disease (AD) therapy. Acteoside (1a) strongly inhibited the aggregation of Aβ42 in a dose-dependent manner. The structure-activity relationship for acteoside (1a) and related compounds suggests the catechol moiety of phenylethanoid glycosides to be essential for this inhibitory activity.

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Year:  2013        PMID： 23748773     DOI： 10.1271/bbb.130101

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  16 in total

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9.  Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer's disease-like rat model: relevance for amyloid deposition and central neurotransmitter function.

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10.  Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives.

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