Literature DB >> 23747242

Novel regulator of enterohepatic bile acid signaling protects against hypercholesterolemia.

Paul A Dawson1.   

Abstract

Hypercholesterolemia is a major cause of cardiovascular disease and can be treated by targeting bile acid and cholesterol metabolism. Vergnes et al. (2013) now identify Diet1 as a novel regulator of fibroblast growth factor 15/19 production and bile acid biosynthesis.
Copyright © 2013 Elsevier Inc. All rights reserved.

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Year:  2013        PMID： 23747242      PMCID： PMC3805117          DOI： 10.1016/j.cmet.2013.05.005

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  9 in total

1.  Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man.

Authors:  T Lundåsen; C Gälman; B Angelin; M Rudling
Journal:  J Intern Med       Date:  2006-12       Impact factor: 8.989

2.  Pronounced variation in bile acid synthesis in humans is related to gender, hypertriglyceridaemia and circulating levels of fibroblast growth factor 19.

Authors:  C Gälman; B Angelin; M Rudling
Journal:  J Intern Med       Date:  2011-11-02       Impact factor: 8.989

3.  Normal plasma cholesterol in an 88-year-old man who eats 25 eggs a day. Mechanisms of adaptation.

Authors:  F Kern
Journal:  N Engl J Med       Date:  1991-03-28       Impact factor: 91.245

4.  The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

Authors:  Jack Phan; Tina Pesaran; Richard C Davis; Karen Reue
Journal:  J Biol Chem       Date:  2001-10-26       Impact factor: 5.157

5.  Regulation of tight junction assembly and epithelial polarity by a resident protein of apical endosomes.

Authors:  Sarah D McCarter; Debra L Johnson; Khameeka N Kitt; Carolyn Donohue; Alison Adams; Jean M Wilson
Journal:  Traffic       Date:  2010-02-27       Impact factor: 6.215

6.  Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

Authors:  Takeshi Inagaki; Mihwa Choi; Antonio Moschetta; Li Peng; Carolyn L Cummins; Jeffrey G McDonald; Guizhen Luo; Stacey A Jones; Bryan Goodwin; James A Richardson; Robert D Gerard; Joyce J Repa; David J Mangelsdorf; Steven A Kliewer
Journal:  Cell Metab       Date:  2005-10       Impact factor: 27.287

7.  Diet1 functions in the FGF15/19 enterohepatic signaling axis to modulate bile acid and lipid levels.

Authors:  Laurent Vergnes; Jessica M Lee; Robert G Chin; Johan Auwerx; Karen Reue
Journal:  Cell Metab       Date:  2013-06-04       Impact factor: 27.287

8.  A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis.

Authors:  Julian R F Walters; Ali M Tasleem; Omer S Omer; W Gordon Brydon; Tracy Dew; Carel W le Roux
Journal:  Clin Gastroenterol Hepatol       Date:  2009-05-06       Impact factor: 11.382

9.  Bile acid excretion and cholesterol 7 alpha-hydroxylase expression in hypercholesterolemia-resistant rabbits.

Authors:  J A Poorman; R A Buck; S A Smith; M L Overturf; D S Loose-Mitchell
Journal:  J Lipid Res       Date:  1993-10       Impact factor: 5.922
  9 in total

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