| Literature DB >> 23747241 |
Abstract
A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.Entities:
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Year: 2013 PMID： 23747241 DOI： 10.1016/j.cmet.2013.05.016
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287