| Literature DB >> 23747240 |
Mario G Mirisola1, Valter D Longo.
Abstract
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.Entities:
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Year: 2013 PMID： 23747240 DOI： 10.1016/j.cmet.2013.05.015
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287