Literature DB >> 23747225

Design and synthesis of N-alkyldeoxynojirimycin derivatives with improved metabolic stability as inhibitors of BVDV and Tacaribe virus.

Yanming Du1, Hong Ye, Fang Guo, Lijuan Wang, Tina Gill, Noshena Khan, Andrea Cuconati, Ju-Tao Guo, Timothy M Block, Jinhong Chang, Xiaodong Xu.   

Abstract

Novel N-alkyldeoxynojirimycins (NADNJs) based on our previous lead 3 were designed, synthesized and tested in metabolic assays and in virus cultures. NADNJs containing terminal tertiary benzamide, sulfonamide, urea, and oxazolidinone moieties were discovered to have improved metabolic stability compared to 3, while maintaining submicromolar EC50 against BVDV and Tacaribe virus; and low cytotoxicity.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 23747225     DOI： 10.1016/j.bmcl.2013.04.052

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Ester Prodrugs of IHVR-19029 with Enhanced Oral Exposure and Prevention of Gastrointestinal Glucosidase Interaction.

Authors:  Julia Ma; Shuo Wu; Xuexiang Zhang; Fang Guo; Katherine Yang; Jia Guo; Qing Su; Huagang Lu; Patrick Lam; Yuhuan Li; Zhengyin Yan; William Kinney; Ju-Tao Guo; Timothy M Block; Jinhong Chang; Yanming Du
Journal:  ACS Med Chem Lett       Date:  2017-01-17       Impact factor: 4.345

2.  Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

Authors:  Julia Ma; Xuexiang Zhang; Veronica Soloveva; Travis Warren; Fang Guo; Shuo Wu; Huagang Lu; Jia Guo; Qing Su; Helen Shen; Eric Solon; Mary Ann Comunale; Anand Mehta; Ju-Tao Guo; Sina Bavari; Yanming Du; Timothy M Block; Jinhong Chang
Journal:  Antiviral Res       Date:  2017-12-15       Impact factor: 5.970

3.  4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators.

Authors:  Nicky Hwang; Haiqun Ban; Shuo Wu; Kelly McGuire; Ellen Hernandez; Junjun Chen; Qiong Zhao; Manasa Suresh; Benjamin Blass; Usha Viswanathan; John Kulp; Jinhong Chang; Jason Clement; Stephan Menne; Ju-Tao Guo; Yanming Du
Journal:  Bioorg Med Chem Lett       Date:  2021-12-31       Impact factor: 2.823
  3 in total

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