Literature DB >> 23747082

Geriatric assessment in older patients with acute myeloid leukemia: a retrospective study of associated treatment and outcomes.

Alexander E Sherman1, Gabriela Motyckova, K Rebecca Fega, Daniel J Deangelo, Gregory A Abel, David Steensma, Martha Wadleigh, Richard M Stone, Jane A Driver.   

Abstract

We explored whether geriatric assessment variables predicted mortality in addition to known prognostic factors in 101 patients aged ≥ 65 with newly diagnosed AML. Baseline comorbidity score (HR=1.92; 95%CI 1.18-3.11), difficulty with strenuous activity (HR=2.18; 95%CI 1.19-4.00), and pain (HR=2.17; 95%CI 1.19-3.97) were independent prognostic factors for greater risk of death in a multivariable model that included cytogenetic risk group. They remained independent predictors in the subset of patients with baseline ECOG PS 0-1. Our results support the use of geriatric assessment to better predict prognosis in older patients with AML, even among those with excellent functional status. Published by Elsevier Ltd.

Entities:  

Keywords:  Acute; Comorbidity; Geriatric assessment; Leukemia; Myeloid; Performance status; Prognosis

Mesh：

Year:  2013        PMID： 23747082      PMCID： PMC3735611          DOI： 10.1016/j.leukres.2013.05.013

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  31 in total

Review 1.  Evaluating the older patient with cancer: understanding frailty and the geriatric assessment.

Authors:  Sumanta Kumar Pal; Vani Katheria; Arti Hurria
Journal:  CA Cancer J Clin       Date:  2010-02-19       Impact factor: 508.702

2.  The haematopoietic cell transplantation comorbidity index score is predictive of early death and survival in patients over 60 years of age receiving induction therapy for acute myeloid leukaemia.

Authors:  Francis J Giles; Gautam Borthakur; Farhad Ravandi; Stefan Faderl; Srdan Verstovsek; Deborah Thomas; William Wierda; Alessandra Ferrajoli; Steven Kornblau; Sherry Pierce; Maher Albitar; Jorge Cortes; Hagop Kantarjian
Journal:  Br J Haematol       Date:  2007-02       Impact factor: 6.998

3.  Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome.

Authors:  Hagop Kantarjian; Susan O'brien; Jorge Cortes; Francis Giles; Stefan Faderl; Elias Jabbour; Guillermo Garcia-Manero; William Wierda; Sherry Pierce; Jianqin Shan; Elihu Estey
Journal:  Cancer       Date:  2006-03-01       Impact factor: 6.860

4.  Addition of lomustine to idarubicin and cytarabine improves the outcome of elderly patients with de novo acute myeloid leukemia: a report from the GOELAMS.

Authors:  Arnaud Pigneux; Jean-Luc Harousseau; Francis Witz; Mathieu Sauvezie; Marie-Christine Bene; Isabelle Luquet; Mathilde Hunault-Berger; Christian Recher; Bruno Lioure; Chantal Himberlin; Martine Escoffre-Barbe; Christian Berthou; Severine Lissandre; Nathalie Fegueux; Jean-Yves Cahn; Eric Jourdan; François Dreyfus; Josy Reiffers; Noël Milpied; Norbert Ifrah
Journal:  J Clin Oncol       Date:  2010-05-17       Impact factor: 44.544

5.  Developing a cancer-specific geriatric assessment: a feasibility study.

Authors:  Arti Hurria; Supriya Gupta; Marjorie Zauderer; Enid L Zuckerman; Harvey J Cohen; Hyman Muss; Miriam Rodin; Katherine S Panageas; Jimmie C Holland; Leonard Saltz; Mark G Kris; Ariela Noy; Jorge Gomez; Ann Jakubowski; Clifford Hudis; Alice B Kornblith
Journal:  Cancer       Date:  2005-11-01       Impact factor: 6.860

6.  Impairment in functional status and survival in patients with acute myeloid leukaemia.

Authors:  Ulrich Wedding; Bernd Röhrig; Almuth Klippstein; Hans-Joerg Fricke; Herbert G Sayer; Klaus Höffken
Journal:  J Cancer Res Clin Oncol       Date:  2006-07-05       Impact factor: 4.553

7.  Comorbidity is an independent predictor of complete remission in elderly patients receiving induction chemotherapy for acute myeloid leukemia.

Authors:  Anne Etienne; Benjamin Esterni; Aude Charbonnier; Marie-Joëlle Mozziconacci; Christine Arnoulet; Diane Coso; Brigitte Puig; Jean-Albert Gastaut; Dominique Maraninchi; Norbert Vey
Journal:  Cancer       Date:  2007-04-01       Impact factor: 6.860

Review 8.  Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.

Authors:  Hartmut Döhner; Elihu H Estey; Sergio Amadori; Frederick R Appelbaum; Thomas Büchner; Alan K Burnett; Hervé Dombret; Pierre Fenaux; David Grimwade; Richard A Larson; Francesco Lo-Coco; Tomoki Naoe; Dietger Niederwieser; Gert J Ossenkoppele; Miguel A Sanz; Jorge Sierra; Martin S Tallman; Bob Löwenberg; Clara D Bloomfield
Journal:  Blood       Date:  2009-10-30       Impact factor: 22.113

9.  Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia.

Authors:  Thomas R Chauncey; Holly Gundacker; Mazyar Shadman; Alan F List; Shaker R Dakhil; Harry P Erba; Marilyn L Slovak; I-Ming Chen; Cheryl L Willman; Kenneth J Kopecky; Frederick R Appelbaum
Journal:  Br J Haematol       Date:  2009-10-11       Impact factor: 6.998

10.  Age and acute myeloid leukemia: real world data on decision to treat and outcomes from the Swedish Acute Leukemia Registry.

Authors:  Gunnar Juliusson; Petar Antunovic; Asa Derolf; Sören Lehmann; Lars Möllgård; Dick Stockelberg; Ulf Tidefelt; Anders Wahlin; Martin Höglund
Journal:  Blood       Date:  2008-11-13       Impact factor: 22.113
View more
  34 in total

Review 1.  Cytotoxic therapy in acute myeloid leukemia: not quite dead yet.

Authors:  Laura C Michaelis
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

Review 2.  Elderly acute myeloid leukemia: assessing risk.

Authors:  Heidi D Klepin
Journal:  Curr Hematol Malig Rep       Date:  2015-06       Impact factor: 3.952

3.  The prognostic importance of polypharmacy in older adults treated for acute myelogenous leukemia (AML).

Authors:  Kathleen Elliot; Janet A Tooze; Rachel Geller; Bayard L Powell; Timothy S Pardee; Ellen Ritchie; LeAnne Kennedy; Kathryn E Callahan; Heidi D Klepin
Journal:  Leuk Res       Date:  2014-07-07       Impact factor: 3.156

4.  Non-hematologic predictors of mortality improve the prognostic value of the international prognostic scoring system for MDS in older adults.

Authors:  K Rebecca Fega; Gregory A Abel; Gabriela Motyckova; Alexander E Sherman; Daniel J DeAngelo; David P Steensma; Ilene Galinsky; Martha Wadleigh; Richard M Stone; Jane A Driver
Journal:  J Geriatr Oncol       Date:  2015-06-11       Impact factor: 3.599

5.  Delivering intensive therapies to older adults with hematologic malignancies: strategies to personalize care.

Authors:  Rebecca L Olin
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2019-12-06

6.  Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia.

Authors:  Heidi D Klepin; Janet A Tooze; Timothy S Pardee; Leslie R Ellis; Dmitriy Berenzon; Shannon L Mihalko; Suzanne C Danhauer; Arati V Rao; Tanya M Wildes; Jeff D Williamson; Bayard L Powell; Stephen B Kritchevsky
Journal:  J Am Geriatr Soc       Date:  2016-09-14       Impact factor: 5.562

Review 7.  Myelodysplastic Syndromes and Acute Myeloid Leukemia in the Elderly.

Authors:  Heidi D Klepin
Journal:  Clin Geriatr Med       Date:  2016-02       Impact factor: 3.076

8.  American Society of Hematology 2020 guidelines for treating newly diagnosed acute myeloid leukemia in older adults.

Authors:  Mikkael A Sekeres; Gordon Guyatt; Gregory Abel; Shabbir Alibhai; Jessica K Altman; Rena Buckstein; Hannah Choe; Pinkal Desai; Harry Erba; Christopher S Hourigan; Thomas W LeBlanc; Mark Litzow; Janet MacEachern; Laura C Michaelis; Sudipto Mukherjee; Kristen O'Dwyer; Ashley Rosko; Richard Stone; Arnav Agarwal; L E Colunga-Lozano; Yaping Chang; QiuKui Hao; Romina Brignardello-Petersen
Journal:  Blood Adv       Date:  2020-08-11

Review 9.  Definition of Unfit for Standard Acute Myeloid Leukemia Therapy.

Authors:  Heidi D Klepin
Journal:  Curr Hematol Malig Rep       Date:  2016-12       Impact factor: 3.952

Review 10.  Management of older or unfit patients with acute myeloid leukemia.

Authors:  R B Walter; E H Estey
Journal:  Leukemia       Date:  2014-07-09       Impact factor: 11.528
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.