OBJECTIVE: Longer duration of untreated psychosis (DUP) is associated with poorer early-course and long-term outcomes, and is a target of early detection and intervention efforts. Given the paucity of research on childhood and adolescent stressors (e.g., maltreatment and neighborhood disorder) as potential predictors of DUP, limited research on premorbid substance use as a determinant of DUP, and inconclusive findings on the association between DUP and neurocognition, we conducted three sets of analyses to address these issues. Mode of onset of psychosis was also considered, given its established role as an illness-level correlate of DUP. METHODS: We rigorously assessed DUP and other pertinent variables in 180 predominantly African American, low-income, and socially disadvantaged first-episode psychosis patients hospitalized in five psychiatric units. RESULTS: Mode of onset of psychosis, prior incarceration, and the level of childhood/adolescent maltreatment were all significant independent predictors of DUP. Regarding premorbid substance use, having ever used cannabis and the amount of premorbid alcohol use were significantly associated with DUP. None of the seven neurocognitive domains assessed were even modestly, or clinically meaningfully, associated with DUP. CONCLUSIONS: These and other findings on DUP may be informative for early detection and intervention services. For example, such services might benefit from special outreach to criminal justice settings and disadvantaged neighborhoods, and to young people likely to have a history of childhood/adolescent maltreatment and gradually developing psychotic symptoms.
OBJECTIVE: Longer duration of untreated psychosis (DUP) is associated with poorer early-course and long-term outcomes, and is a target of early detection and intervention efforts. Given the paucity of research on childhood and adolescent stressors (e.g., maltreatment and neighborhood disorder) as potential predictors of DUP, limited research on premorbid substance use as a determinant of DUP, and inconclusive findings on the association between DUP and neurocognition, we conducted three sets of analyses to address these issues. Mode of onset of psychosis was also considered, given its established role as an illness-level correlate of DUP. METHODS: We rigorously assessed DUP and other pertinent variables in 180 predominantly African American, low-income, and socially disadvantaged first-episode psychosispatients hospitalized in five psychiatric units. RESULTS: Mode of onset of psychosis, prior incarceration, and the level of childhood/adolescent maltreatment were all significant independent predictors of DUP. Regarding premorbid substance use, having ever used cannabis and the amount of premorbid alcohol use were significantly associated with DUP. None of the seven neurocognitive domains assessed were even modestly, or clinically meaningfully, associated with DUP. CONCLUSIONS: These and other findings on DUP may be informative for early detection and intervention services. For example, such services might benefit from special outreach to criminal justice settings and disadvantaged neighborhoods, and to young people likely to have a history of childhood/adolescent maltreatment and gradually developing psychotic symptoms.
Authors: Michael T Compton; Victoria H Chien; Amy S Leiner; Sandra M Goulding; Paul S Weiss Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2008-07-05 Impact factor: 4.328
Authors: Michael T Compton; Tynessa L Gordon; Sandra M Goulding; Michelle L Esterberg; Tandrea Carter; Amy S Leiner; Paul S Weiss; Benjamin G Druss; Elaine F Walker; Nadine J Kaslow Journal: J Clin Psychiatry Date: 2011-02 Impact factor: 4.384
Authors: H E Becker; D H Nieman; S Wiltink; P M Dingemans; J R van de Fliert; E Velthorst; L de Haan; T A van Amelsvoort; D H Linszen Journal: Psychol Med Date: 2010-02-05 Impact factor: 7.723
Authors: D P Bernstein; L Fink; L Handelsman; J Foote; M Lovejoy; K Wenzel; E Sapareto; J Ruggiero Journal: Am J Psychiatry Date: 1994-08 Impact factor: 18.112
Authors: Robert S Kern; Keith H Nuechterlein; Michael F Green; Lyle E Baade; Wayne S Fenton; James M Gold; Richard S E Keefe; Raquelle Mesholam-Gately; Jim Mintz; Larry J Seidman; Ellen Stover; Stephen R Marder Journal: Am J Psychiatry Date: 2008-01-02 Impact factor: 18.112
Authors: Julia M Lappin; Kevin D Morgan; Craig Morgan; Paola Dazzan; Abraham Reichenberg; Jolanta W Zanelli; Paul Fearon; Peter B Jones; Tuhina Lloyd; Jane Tarrant; Annette Farrant; Julian Leff; Robin M Murray Journal: Schizophr Res Date: 2007-07-20 Impact factor: 4.939
Authors: Mary E Kelley; Claire Ramsay Wan; Beth Broussard; Anthony Crisafio; Sarah Cristofaro; Stephanie Johnson; Thomas A Reed; Patrick Amar; Nadine J Kaslow; Elaine F Walker; Michael T Compton Journal: Schizophr Res Date: 2016-01-17 Impact factor: 4.939
Authors: Abdülkadir Tabo; Erkan Aydın; Hüseyin Yumrukçal; Sadık Yiğit; Uğraş Erman Uzun; Oğuz Karamustafalıoğlu Journal: Community Ment Health J Date: 2017-02-10
Authors: Glen P Davis; Andrew Tomita; Joy Noel Baumgartner; Sisanda Mtshemla; Siphumelele Nene; Howard King; Ezra Susser; Jonathan K Burns Journal: S Afr J Psychiatr Date: 2016-05-20 Impact factor: 1.550
Authors: J B Kirkbride; J Stochl; J Zimbrón; C M Crane; A Metastasio; E Aguilar; R Webster; S Theegala; N Kabacs; P B Jones; J Perez Journal: Acta Psychiatr Scand Date: 2014-12-31 Impact factor: 6.392