Buxian Tian1, Yuhong Zhang, Nan Li. 1. Department of Neurology, First Affiliated Hospital of Liaoning Medical College, Jinzhou, China.
Abstract
OBJECTIVE: To study the expression and regulatory effects of CD146 protein in colorectal cancer and the correlation between CD146 protein expression and the prognosis of colorectal cancer. MATERIALS AND METHODS: The CD146 protein level was detected by immunohistochemistry staining. The relationship between CD146 expression and clinicopathological parameters of colorectal cancer was determined. RESULTS: It was observed that 216 (20.00%) of the 1080 cases positively expressed CD146 protein. Univariate analyses indicated that CD146 expression was related to histological grade, Duke's stage, and liver metastasis (p=0.001, 0.001, and 0.001, respectively). Spearman correlation analysis showed that CD146 expression has line correlation to histological grade, Duke's stage, and liver metastasis (p=0.02, 0.01 and 0.001, respectively). After multivariate analysis, Duke's stage and CD146 were related to liver metastasis (p=0.01 and 0.001, respectively). In the Cox regression test, histological grade, Duke's stage, and CD146 were detected as the independent prognostic factors (p=0.045, 0.01, and 0.001, respectively). CONCLUSIONS: CD146 protein may be a potential biomarker for the postoperative liver metastasis of colorectal cancer.
OBJECTIVE: To study the expression and regulatory effects of CD146 protein in colorectal cancer and the correlation between CD146 protein expression and the prognosis of colorectal cancer. MATERIALS AND METHODS: The CD146 protein level was detected by immunohistochemistry staining. The relationship between CD146 expression and clinicopathological parameters of colorectal cancer was determined. RESULTS: It was observed that 216 (20.00%) of the 1080 cases positively expressed CD146 protein. Univariate analyses indicated that CD146 expression was related to histological grade, Duke's stage, and liver metastasis (p=0.001, 0.001, and 0.001, respectively). Spearman correlation analysis showed that CD146 expression has line correlation to histological grade, Duke's stage, and liver metastasis (p=0.02, 0.01 and 0.001, respectively). After multivariate analysis, Duke's stage and CD146 were related to liver metastasis (p=0.01 and 0.001, respectively). In the Cox regression test, histological grade, Duke's stage, and CD146 were detected as the independent prognostic factors (p=0.045, 0.01, and 0.001, respectively). CONCLUSIONS:CD146 protein may be a potential biomarker for the postoperative liver metastasis of colorectal cancer.
Authors: Hiroki Kobayashi; Krystyna A Gieniec; Tamsin R M Lannagan; Tongtong Wang; Naoya Asai; Yasuyuki Mizutani; Tadashi Iida; Ryota Ando; Elaine M Thomas; Akihiro Sakai; Nobumi Suzuki; Mari Ichinose; Josephine A Wright; Laura Vrbanac; Jia Q Ng; Jarrad Goyne; Georgette Radford; Matthew J Lawrence; Tarik Sammour; Yoku Hayakawa; Sonja Klebe; Alice E Shin; Samuel Asfaha; Mark L Bettington; Florian Rieder; Nicholas Arpaia; Tal Danino; Lisa M Butler; Alastair D Burt; Simon J Leedham; Anil K Rustgi; Siddhartha Mukherjee; Masahide Takahashi; Timothy C Wang; Atsushi Enomoto; Susan L Woods; Daniel L Worthley Journal: Gastroenterology Date: 2021-12-06 Impact factor: 33.883
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