| Literature DB >> 23745547 |
M Chen1, T M Curtis, A W Stitt.
Abstract
Diabetic retinopathy (DR) has a complex pathogenesis which is impacted by a raft of systemic abnormalities and tissue-specific alterations occurring in response to the diabetes milieu. Many pathogenic processes play key roles in retinal damage in diabetic patients. One such pathway is the formation and accumulation of advanced glycation endproducts (AGEs) and advanced lipoxidation end products (ALEs) which are relevant modifications with roles in the initiation and progression of pathology. In this review, AGE/ALE formation in the diabetic retina is discussed alongside their impact on retinal cell function. In addition, various inhibitors of the AGE-RAGE system and their therapeutic utility for DR will also be evaluated.Entities:
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Year: 2013 PMID： 23745547 DOI： 10.2174/09298673113209990025
Source DB: PubMed Journal: Curr Med Chem ISSN： 0929-8673 Impact factor: 4.530