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Literature DB >> 23744811

Probing the dimerization interface of Leishmania infantum trypanothione reductase with site-directed mutagenesis and short peptides.

Miguel A Toro¹, Pedro A Sánchez-Murcia, David Moreno, Marta Ruiz-Santaquiteria, Juan Fernando Alzate, Ana Negri, María-José Camarasa, Federico Gago, Sonsoles Velázquez, Antonio Jiménez-Ruiz.

Abstract

Binding at the interface: We tested the inhibitory activity of a set of peptide sequences derived from an α-helix of the dimeric trypanothione reductase from Leishmania infantum. Replacement of a glutamic acid residue with a lysine promoted monomer dissociation and enzyme inhibition.

Entities: Chemical Species

Keywords: Leishmania; dimer quantification assay; enzyme models; protein-protein interactions; trypanothione reductase

Mesh：

Substances：

Year: 2013 PMID： 23744811 DOI： 10.1002/cbic.201200744

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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Cited

10 in total

1. Pseudoirreversible slow-binding inhibition of trypanothione reductase by a protein-protein interaction disruptor.

Authors: Héctor de Lucio; Miguel A Toro; María-José Camarasa; Sonsoles Velázquez; Federico Gago; Antonio Jiménez-Ruiz
Journal: Br J Pharmacol Date: 2020-10-02 Impact factor: 8.739

2. Synthesis and Leishmanicidal Activity of Novel Urea, Thiourea, and Selenourea Derivatives of Diselenides.

Authors: Marta Díaz; Héctor de Lucio; Esther Moreno; Socorro Espuelas; Carlos Aydillo; Antonio Jiménez-Ruiz; Miguel Ángel Toro; Killian Jesús Gutiérrez; Victor Martínez-Merino; Alfonso Cornejo; Juan Antonio Palop; Carmen Sanmartín; Daniel Plano
Journal: Antimicrob Agents Chemother Date: 2019-04-25 Impact factor: 5.191

3. Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents.

Authors: Ylenia Baquedano; Verónica Alcolea; Miguel Ángel Toro; Killian Jesús Gutiérrez; Paul Nguewa; María Font; Esther Moreno; Socorro Espuelas; Antonio Jiménez-Ruiz; Juan Antonio Palop; Daniel Plano; Carmen Sanmartín
Journal: Antimicrob Agents Chemother Date: 2016-05-23 Impact factor: 5.191

4. New Amides Containing Selenium as Potent Leishmanicidal Agents Targeting Trypanothione Reductase.

Authors: Mikel Etxebeste-Mitxeltorena; Daniel Plano; Socorro Espuelas; Esther Moreno; Carlos Aydillo; Antonio Jiménez-Ruiz; Juan Carlos García Soriano; Carmen Sanmartín
Journal: Antimicrob Agents Chemother Date: 2020-12-16 Impact factor: 5.191

5. Druggable hot spots in trypanothione reductase: novel insights and opportunities for drug discovery revealed by DRUGpy.

Authors: Olivia Teixeira; Pedro Lacerda; Thamires Quadros Froes; Maria Cristina Nonato; Marcelo Santos Castilho
Journal: J Comput Aided Mol Des Date: 2021-06-28 Impact factor: 3.686

6. Essential multimeric enzymes in kinetoplastid parasites: A host of potentially druggable protein-protein interactions.

Authors: Leah M Wachsmuth; Meredith G Johnson; Jason Gavenonis
Journal: PLoS Negl Trop Dis Date: 2017-06-29

Review 7. Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases.

Authors: Theo Battista; Gianni Colotti; Andrea Ilari; Annarita Fiorillo
Journal: Molecules Date: 2020-04-21 Impact factor: 4.411