Literature DB >> 23744136

Heavy drugs draw heavy interest from pharma backers.

Alla Katsnelson.   

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Year:  2013        PMID： 23744136     DOI： 10.1038/nm0613-656

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


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  1 in total

1.  Effect of Deuterium Substitution in Sympathomimetic Amines on Adrenergic Responses.

Authors:  B Belleau; J Burba; M Pindell; J Reiffenstein
Journal:  Science       Date:  1961-01-13       Impact factor: 47.728
  1 in total
  33 in total

1.  Hydrogen-deuterium exchange of aromatic amines and amides using deuterated trifluoroacetic acid.

Authors:  Richard Giles; Amy Lee; Erica Jung; Aaron Kang; Kyung Woon Jung
Journal:  Tetrahedron Lett       Date:  2015-01-28       Impact factor: 2.415

2.  Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties.

Authors:  Yanmei Zhang; Micky D Tortorella; Yican Wang; Jianqi Liu; Zhengchao Tu; Xiaorong Liu; Yang Bai; Dingsheng Wen; Xin Lu; Yongzhi Lu; John J Talley
Journal:  ACS Med Chem Lett       Date:  2014-07-27       Impact factor: 4.345

Review 3.  Deuterated drugs: where are we now?

Authors:  Graham S Timmins
Journal:  Expert Opin Ther Pat       Date:  2014-07-29       Impact factor: 6.674

4.  A Phase I dose-escalation, pharmacokinetics and food-effect study of oral donafenib in patients with advanced solid tumours.

Authors:  Xiaoyu Li; Meng Qiu; Li Zheng; ShengJun Wang; Hong Zhu; Bi Feng
Journal:  Cancer Chemother Pharmacol       Date:  2020-02-01       Impact factor: 3.333

5.  Trideuteromethylation Enabled by a Sulfoxonium Metathesis Reaction.

Authors:  Zuyuan Shen; Shilei Zhang; Huihui Geng; Jiarui Wang; Xinyu Zhang; Anqi Zhou; Cheng Yao; Xiaobei Chen; Wei Wang
Journal:  Org Lett       Date:  2019-01-07       Impact factor: 6.005

6.  Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.

Authors:  Kyle Parcella; Kyle Eastman; Kap-Sun Yeung; Katharine A Grant-Young; Juliang Zhu; Tao Wang; Zhongxing Zhang; Zhiwei Yin; Dawn Parker; Kathy Mosure; Hua Fang; Ying-Kai Wang; Julie Lemm; Xiaoliang Zhuo; Umesh Hanumegowda; Mengping Liu; Karen Rigat; Maria Donoso; Maria Tuttle; Tatyana Zvyaga; Zuzana Haarhoff; Nicholas A Meanwell; Matthew G Soars; Susan B Roberts; John F Kadow
Journal:  ACS Med Chem Lett       Date:  2017-06-29       Impact factor: 4.345

7.  Heavy Heparin: A Stable Isotope-Enriched, Chemoenzymatically-Synthesized, Poly-Component Drug.

Authors:  Brady F Cress; Ujjwal Bhaskar; Deepika Vaidyanathan; Asher Williams; Chao Cai; Xinyue Liu; Li Fu; Vandhana M-Chari; Fuming Zhang; Shaker A Mousa; Jonathan S Dordick; Mattheos A G Koffas; Robert J Linhardt
Journal:  Angew Chem Int Ed Engl       Date:  2019-04-01       Impact factor: 15.336

Review 8.  Dissecting fibrosis: therapeutic insights from the small-molecule toolbox.

Authors:  Carmel B Nanthakumar; Richard J D Hatley; Seble Lemma; Jack Gauldie; Richard P Marshall; Simon J F Macdonald
Journal:  Nat Rev Drug Discov       Date:  2015-09-04       Impact factor: 84.694

9.  Cobalt-Catalyzed Stereoretentive Hydrogen Isotope Exchange of C(sp3)-H Bonds.

Authors:  W Neil Palmer; Paul J Chirik
Journal:  ACS Catal       Date:  2017-07-28       Impact factor: 13.084

10.  Palladium/Rhodium Cooperative Catalysis for the Production of Aryl Aldehydes and Their Deuterated Analogues Using the Water-Gas Shift Reaction.

Authors:  Malek Y S Ibrahim; Scott E Denmark
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-17       Impact factor: 15.336
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