Literature DB >> 23743722

Progress in HIV-1 vaccine development.

Barton F Haynes1, M Juliana McElrath.   

Abstract

PURPOSE OF REVIEW: In this review, examples of recent progress in HIV-1 vaccine research are discussed. RECENT
FINDINGS: New insights from the immune correlates analyses of the RV144 efficacy trial have accelerated vaccine development with leads to follow in nonhuman primate studies and improved vaccine designs. Several new vaccine vector approaches offer promise in the exquisite control of acute infection and in improving the breadth of T-cell responses. New targets of broadly neutralizing antibodies (BnAbs) have been elucidated, and improved understanding of how the human host controls BnAb development have emerged from BnAb knock-in mice and from analyses of BnAb maturation and virus evolution in individuals followed from the time of HIV-1 transmission to BnAb induction.
SUMMARY: Based on these observations, it is clear that the development of a successful HIV-1 vaccine will require new vaccine approaches and iterative testing of immunogens in well designed animal and human trials.

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Year:  2013        PMID： 23743722      PMCID： PMC3947525          DOI： 10.1097/COH.0b013e328361d178

Source DB:  PubMed          Journal:  Curr Opin HIV AIDS        ISSN： 1746-630X            Impact factor:   4.283


  73 in total

1.  Full-length HIV-1 immunogens induce greater magnitude and comparable breadth of T lymphocyte responses to conserved HIV-1 regions compared with conserved-region-only HIV-1 immunogens in rhesus monkeys.

Authors:  Kathryn E Stephenson; Adam SanMiguel; Nathaniel L Simmons; Kaitlin Smith; Mark G Lewis; James J Szinger; Bette Korber; Dan H Barouch
Journal:  J Virol       Date:  2012-08-15       Impact factor: 5.103

2.  Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.

Authors:  Paul A Goepfert; Georgia D Tomaras; Helen Horton; David Montefiori; Guido Ferrari; Mark Deers; Gerald Voss; Marguerite Koutsoukos; Louise Pedneault; Pierre Vandepapeliere; M Juliana McElrath; Paul Spearman; Jonathan D Fuchs; Beryl A Koblin; William A Blattner; Sharon Frey; Lindsey R Baden; Clayton Harro; Thomas Evans
Journal:  Vaccine       Date:  2006-08-10       Impact factor: 3.641

3.  Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls.

Authors:  Laurent Verkoczy; Yao Chen; Hilary Bouton-Verville; Jinsong Zhang; Marilyn Diaz; Jennifer Hutchinson; Ying-Bin Ouyang; S Munir Alam; T Matt Holl; Kwan-Ki Hwang; Garnett Kelsoe; Barton F Haynes
Journal:  J Immunol       Date:  2011-09-09       Impact factor: 5.422

4.  Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys.

Authors:  Sampa Santra; Hua-Xin Liao; Ruijin Zhang; Mark Muldoon; Sydeaka Watson; Will Fischer; James Theiler; James Szinger; Harikrishnan Balachandran; Adam Buzby; David Quinn; Robert J Parks; Chun-Yen Tsao; Angela Carville; Keith G Mansfield; George N Pavlakis; Barbara K Felber; Barton F Haynes; Bette T Korber; Norman L Letvin
Journal:  Nat Med       Date:  2010-02-21       Impact factor: 53.440

5.  Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Authors:  Hua-Xin Liao; Mattia Bonsignori; S Munir Alam; Jason S McLellan; Georgia D Tomaras; M Anthony Moody; Daniel M Kozink; Kwan-Ki Hwang; Xi Chen; Chun-Yen Tsao; Pinghuang Liu; Xiaozhi Lu; Robert J Parks; David C Montefiori; Guido Ferrari; Justin Pollara; Mangala Rao; Kristina K Peachman; Sampa Santra; Norman L Letvin; Nicos Karasavvas; Zhi-Yong Yang; Kaifan Dai; Marie Pancera; Jason Gorman; Kevin Wiehe; Nathan I Nicely; Supachai Rerks-Ngarm; Sorachai Nitayaphan; Jaranit Kaewkungwal; Punnee Pitisuttithum; James Tartaglia; Faruk Sinangil; Jerome H Kim; Nelson L Michael; Thomas B Kepler; Peter D Kwong; John R Mascola; Gary J Nabel; Abraham Pinter; Susan Zolla-Pazner; Barton F Haynes
Journal:  Immunity       Date:  2013-01-11       Impact factor: 31.745

Review 6.  A Blueprint for HIV Vaccine Discovery.

Authors:  Dennis R Burton; Rafi Ahmed; Dan H Barouch; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Richard Wyatt
Journal:  Cell Host Microbe       Date:  2012-10-18       Impact factor: 21.023

7.  Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial.

Authors:  Morgane Rolland; Sodsai Tovanabutra; Allan C deCamp; Nicole Frahm; Peter B Gilbert; Eric Sanders-Buell; Laura Heath; Craig A Magaret; Meera Bose; Andrea Bradfield; Annemarie O'Sullivan; Jacqueline Crossler; Teresa Jones; Marty Nau; Kim Wong; Hong Zhao; Dana N Raugi; Stephanie Sorensen; Julia N Stoddard; Brandon S Maust; Wenjie Deng; John Hural; Sheri Dubey; Nelson L Michael; John Shiver; Lawrence Corey; Fusheng Li; Steve G Self; Jerome Kim; Susan Buchbinder; Danilo R Casimiro; Michael N Robertson; Ann Duerr; M Juliana McElrath; Francine E McCutchan; James I Mullins
Journal:  Nat Med       Date:  2011-02-27       Impact factor: 53.440

8.  H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.

Authors:  M Anthony Moody; Ruijun Zhang; Emmanuel B Walter; Christopher W Woods; Geoffrey S Ginsburg; Micah T McClain; Thomas N Denny; Xi Chen; Supriya Munshaw; Dawn J Marshall; John F Whitesides; Mark S Drinker; Joshua D Amos; Thaddeus C Gurley; Joshua A Eudailey; Andrew Foulger; Katherine R DeRosa; Robert Parks; R Ryan Meyerhoff; Jae-Sung Yu; Daniel M Kozink; Brice E Barefoot; Elizabeth A Ramsburg; Surender Khurana; Hana Golding; Nathan A Vandergrift; S Munir Alam; Georgia D Tomaras; Thomas B Kepler; Garnett Kelsoe; Hua-Xin Liao; Barton F Haynes
Journal:  PLoS One       Date:  2011-10-19       Impact factor: 3.240

9.  Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.

Authors:  Xiaodong Xiao; Weizao Chen; Yang Feng; Zhongyu Zhu; Ponraj Prabakaran; Yanping Wang; Mei-Yun Zhang; Nancy S Longo; Dimiter S Dimitrov
Journal:  Biochem Biophys Res Commun       Date:  2009-09-11       Impact factor: 3.575

10.  Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2.

Authors:  Morgane Rolland; Paul T Edlefsen; Brendan B Larsen; Sodsai Tovanabutra; Eric Sanders-Buell; Tomer Hertz; Allan C deCamp; Chris Carrico; Sergey Menis; Craig A Magaret; Hasan Ahmed; Michal Juraska; Lennie Chen; Philip Konopa; Snehal Nariya; Julia N Stoddard; Kim Wong; Hong Zhao; Wenjie Deng; Brandon S Maust; Meera Bose; Shana Howell; Adam Bates; Michelle Lazzaro; Annemarie O'Sullivan; Esther Lei; Andrea Bradfield; Grace Ibitamuno; Vatcharain Assawadarachai; Robert J O'Connell; Mark S deSouza; Sorachai Nitayaphan; Supachai Rerks-Ngarm; Merlin L Robb; Jason S McLellan; Ivelin Georgiev; Peter D Kwong; Jonathan M Carlson; Nelson L Michael; William R Schief; Peter B Gilbert; James I Mullins; Jerome H Kim
Journal:  Nature       Date:  2012-09-10       Impact factor: 49.962
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  31 in total

1.  Which comes first: the antigen or the adjuvant?

Authors:  Sallie R Permar; Herman F Staats
Journal:  J Clin Invest       Date:  2014-05-16       Impact factor: 14.808

2.  Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

Authors:  Ivelin S Georgiev; M Gordon Joyce; Yongping Yang; Mallika Sastry; Baoshan Zhang; Ulrich Baxa; Rita E Chen; Aliaksandr Druz; Christopher R Lees; Sandeep Narpala; Arne Schön; Joseph Van Galen; Gwo-Yu Chuang; Jason Gorman; Adam Harned; Marie Pancera; Guillaume B E Stewart-Jones; Cheng Cheng; Ernesto Freire; Adrian B McDermott; John R Mascola; Peter D Kwong
Journal:  J Virol       Date:  2015-03-04       Impact factor: 5.103

3.  CD4 mimetics sensitize HIV-1-infected cells to ADCC.

Authors:  Jonathan Richard; Maxime Veillette; Nathalie Brassard; Shilpa S Iyer; Michel Roger; Loïc Martin; Marzena Pazgier; Arne Schön; Ernesto Freire; Jean-Pierre Routy; Amos B Smith; Jongwoo Park; David M Jones; Joel R Courter; Bruno N Melillo; Daniel E Kaufmann; Beatrice H Hahn; Sallie R Permar; Barton F Haynes; Navid Madani; Joseph G Sodroski; Andrés Finzi
Journal:  Proc Natl Acad Sci U S A       Date:  2015-05-04       Impact factor: 11.205

Review 4.  Progress in HIV-1 vaccine development.

Authors:  Barton F Haynes; M Anthony Moody; Munir Alam; Mattia Bonsignori; Laurent Verkoczy; Guido Ferrari; Feng Gao; Georgia D Tomaras; Hua-Xin Liao; Garnett Kelsoe
Journal:  J Allergy Clin Immunol       Date:  2014-06-26       Impact factor: 10.793

5.  Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds.

Authors:  Navid Madani; Amy M Princiotto; David Easterhoff; Todd Bradley; Kan Luo; Wilton B Williams; Hua-Xin Liao; M Anthony Moody; Ganesh E Phad; Néstor Vázquez Bernat; Bruno Melillo; Sampa Santra; Amos B Smith; Gunilla B Karlsson Hedestam; Barton Haynes; Joseph Sodroski
Journal:  J Virol       Date:  2016-04-29       Impact factor: 5.103

6.  Activated CD4+CCR5+ T cells in the rectum predict increased SIV acquisition in SIVGag/Tat-vaccinated rhesus macaques.

Authors:  Diane G Carnathan; Katherine S Wetzel; Joana Yu; S Thera Lee; Brent A Johnson; Mirko Paiardini; Jian Yan; Matthew P Morrow; Niranjan Y Sardesai; David B Weiner; Hildegund C J Ertl; Guido Silvestri
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-30       Impact factor: 11.205

7.  Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.

Authors:  Smita S Iyer; Sailaja Gangadhara; Blandine Victor; Rosy Gomez; Rahul Basu; Jung Joo Hong; Celia Labranche; David C Montefiori; Francois Villinger; Bernard Moss; Rama Rao Amara
Journal:  J Immunol       Date:  2015-06-26       Impact factor: 5.422

8.  Rapid Development of gp120-Focused Neutralizing B Cell Responses during Acute Simian Immunodeficiency Virus Infection of African Green Monkeys.

Authors:  Joshua D Amos; Jonathon E Himes; Lawrence Armand; Thaddeus C Gurley; David R Martinez; Lisa Colvin; Krista Beck; R Glenn Overman; Hua-Xin Liao; M Anthony Moody; Sallie R Permar
Journal:  J Virol       Date:  2015-07-08       Impact factor: 5.103

9.  HIV-1 envelope proteins and V1/V2 domain scaffolds with mannose-5 to improve the magnitude and quality of protective antibody responses to HIV-1.

Authors:  Javier F Morales; Trevor J Morin; Bin Yu; Gwen P Tatsuno; Sara M O'Rourke; Richard Theolis; Kathryn A Mesa; Phillip W Berman
Journal:  J Biol Chem       Date:  2014-07-25       Impact factor: 5.157

10.  Effect of vaginal immunization with HIVgp140 and HSP70 on HIV-1 replication and innate and T cell adaptive immunity in women.

Authors:  David J M Lewis; Yufei Wang; Zhiming Huo; Raphaela Giemza; Kaboutar Babaahmady; Durdana Rahman; Robin J Shattock; Mahavir Singh; Thomas Lehner
Journal:  J Virol       Date:  2014-07-09       Impact factor: 5.103
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