OBJECTIVE: To evaluate whether supplemental perioperative oxygen decreases surgical site wound infections or endometritis. STUDY DESIGN: This was a prospective, randomized trial. Patients who were to undergo cesarean delivery were recruited and randomly allocated to either 30% or 80% oxygen during the cesarean delivery and for 1 hour after surgery. The obstetricians and patients were blinded to the concentration of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis. RESULTS:Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively. CONCLUSION: Women who received 80% supplemental oxygen perioperatively did not have a lower rate of a surgical site infection or endometritis as compared with women who received 30% supplemental oxygen concentration. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clincaltrials.gov, NCT00876005. LEVEL OF EVIDENCE: I.
RCT Entities:
OBJECTIVE: To evaluate whether supplemental perioperative oxygen decreases surgical site wound infections or endometritis. STUDY DESIGN: This was a prospective, randomized trial. Patients who were to undergo cesarean delivery were recruited and randomly allocated to either 30% or 80% oxygen during the cesarean delivery and for 1 hour after surgery. The obstetricians and patients were blinded to the concentration of oxygen used. Patients were evaluated for wound infection or endometritis during their hospital stay and by 6 weeks postpartum. The primary end point was a composite of either surgical site infection or endometritis. RESULTS: Eight hundred thirty-one patients were recruited. Of these, 415 participants received 30% oxygen perioperatively and 416 received 80% oxygen. The groups were well matched for age, race, parity, diabetes, number of previous cesarean deliveries, and scheduled compared with unscheduled cesarean deliveries. An intention-to-treat analysis was used. There was no difference in the primary composite outcome (8.2% in women who received 30% oxygen compared with 8.2% in women who received 80% oxygen, P=.89), no difference in surgical site infection in the two groups (5.5% compared with 5.8%, P=.98), and no significant difference in endometritis in the two groups (2.7% compared with 2.4%, P=.66), respectively. CONCLUSION:Women who received 80% supplemental oxygen perioperatively did not have a lower rate of a surgical site infection or endometritis as compared with women who received 30% supplemental oxygen concentration. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clincaltrials.gov, NCT00876005. LEVEL OF EVIDENCE: I.
Authors: Grace Lim; Francesca L Facco; Naveen Nathan; Jonathan H Waters; Cynthia A Wong; Holger K Eltzschig Journal: Anesthesiology Date: 2018-07 Impact factor: 7.892
Authors: Ozan Akca; Lorenzo Ball; F Javier Belda; Peter Biro; Andrea Cortegiani; Arieh Eden; Carlos Ferrando; Luciano Gattinoni; Zeev Goldik; Cesare Gregoretti; Thomas Hachenberg; Göran Hedenstierna; Harriet W Hopf; Thomas K Hunt; Paolo Pelosi; Motaz Qadan; Daniel I Sessler; Marina Soro; Mert Şentürk Journal: Turk J Anaesthesiol Reanim Date: 2017-08-01
Authors: Jørn Wetterslev; Christian S Meyhoff; Lars N Jørgensen; Christian Gluud; Jane Lindschou; Lars S Rasmussen Journal: Cochrane Database Syst Rev Date: 2015-06-25