SETTING: Mycobacterium tuberculosis comprises four principal genetic lineages: one evolutionarily ancestral (Indo-Oceanic) and three modern. Whether response to tuberculosis (TB) treatment differs among the lineages is unknown. OBJECTIVE: To examine the association between M. tuberculosis lineage and time to sputum culture conversion in response to standard first-line drug therapy. DESIGN: We conducted an exploratory retrospective cohort analysis of time to sputum culture conversion among pulmonary tuberculosis (PTB) cases reported in the United States from 2004 to 2007. RESULTS: The analysis included 13,170 PTB cases with no documented resistance to first-line drugs who received a standard four-drug treatment regimen. Among cases with baseline positive sputum smear results, relative to cases with Euro-American lineage, cases with Indo-Oceanic lineage had higher adjusted hazards of sputum culture conversion (aHR 1.32, 95%CI 1.20-1.45), whereas cases with East-African-Indian or East-Asian lineage did not differ (aHR 1.05, 95%CI 0.88-1.25 and aHR 0.99, 95%CI 0.91-1.07, respectively). Among cases with baseline negative sputum smear results, time to sputum culture conversion did not differ by lineage. CONCLUSION: Although these results are exploratory, they suggest that the eradication of viable bacteria may occur sooner among cases with Indo-Oceanic lineage than among those with one of the three modern lineages. Prospective studies of time to sputum culture conversion by lineage are required.
SETTING:Mycobacterium tuberculosis comprises four principal genetic lineages: one evolutionarily ancestral (Indo-Oceanic) and three modern. Whether response to tuberculosis (TB) treatment differs among the lineages is unknown. OBJECTIVE: To examine the association between M. tuberculosis lineage and time to sputum culture conversion in response to standard first-line drug therapy. DESIGN: We conducted an exploratory retrospective cohort analysis of time to sputum culture conversion among pulmonary tuberculosis (PTB) cases reported in the United States from 2004 to 2007. RESULTS: The analysis included 13,170 PTB cases with no documented resistance to first-line drugs who received a standard four-drug treatment regimen. Among cases with baseline positive sputum smear results, relative to cases with Euro-American lineage, cases with Indo-Oceanic lineage had higher adjusted hazards of sputum culture conversion (aHR 1.32, 95%CI 1.20-1.45), whereas cases with East-African-Indian or East-Asian lineage did not differ (aHR 1.05, 95%CI 0.88-1.25 and aHR 0.99, 95%CI 0.91-1.07, respectively). Among cases with baseline negative sputum smear results, time to sputum culture conversion did not differ by lineage. CONCLUSION: Although these results are exploratory, they suggest that the eradication of viable bacteria may occur sooner among cases with Indo-Oceanic lineage than among those with one of the three modern lineages. Prospective studies of time to sputum culture conversion by lineage are required.
Authors: J A Guerra-Assunção; A C Crampin; R M G J Houben; T Mzembe; K Mallard; F Coll; P Khan; L Banda; A Chiwaya; R P A Pereira; R McNerney; P E M Fine; J Parkhill; T G Clark; J R Glynn Journal: Elife Date: 2015-03-03 Impact factor: 8.140
Authors: L D Tientcheu; J Maertzdorf; J Weiner; I M Adetifa; H-J Mollenkopf; J S Sutherland; S Donkor; B Kampmann; S H E Kaufmann; H M Dockrell; M O Ota Journal: Genes Immun Date: 2015-06-04 Impact factor: 2.676
Authors: Claire J Calderwood; James P Wilson; Katherine L Fielding; Rebecca C Harris; Aaron S Karat; Raoul Mansukhani; Jane Falconer; Malin Bergstrom; Sarah M Johnson; Nicky McCreesh; Edward J M Monk; Jasantha Odayar; Peter J Scott; Sarah A Stokes; Hannah Theodorou; David A J Moore Journal: PLoS Med Date: 2021-04-26 Impact factor: 11.069
Authors: Leopold D Tientcheu; Mariëlle C Haks; Schadrac C Agbla; Jayne S Sutherland; Ifedayo M Adetifa; Simon Donkor; Edwin Quinten; Mohammed Daramy; Martin Antonio; Beate Kampmann; Tom H M Ottenhoff; Hazel M Dockrell; Martin O Ota Journal: PLoS Negl Trop Dis Date: 2016-05-18
Authors: Colleen Scott; Joseph S Cavanaugh; Benjamin J Silk; Julia Ershova; Gerald H Mazurek; Philip A LoBue; Patrick K Moonan Journal: Emerg Infect Dis Date: 2017-03 Impact factor: 6.883
Authors: Kirsten E Wiens; Lauren P Woyczynski; Jorge R Ledesma; Jennifer M Ross; Roberto Zenteno-Cuevas; Amador Goodridge; Irfan Ullah; Barun Mathema; Joel Fleury Djoba Siawaya; Molly H Biehl; Sarah E Ray; Natalia V Bhattacharjee; Nathaniel J Henry; Robert C Reiner; Hmwe H Kyu; Christopher J L Murray; Simon I Hay Journal: BMC Med Date: 2018-10-30 Impact factor: 8.775