Chizuko Yokoe1, Hiroshi Hanamoto2, Aiji Boku2, Mitsutaka Sugimura3, Yoshinari Morimoto3, Chiho Kudo2, Hitoshi Niwa4. 1. Clinical Fellow, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan. 2. Assistant Professor, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan. 3. Associate Professor, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan. 4. Professor, Department of Dental Anesthesiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan. Electronic address: hanamoto@dent.osaka-u.ac.jp.
Abstract
OBJECTIVE: Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation. STUDY DESIGN:Twenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n=13) or a combined technique using 20% N2O and propofol (group N+P, n=13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5μg/mL. Hemodynamic and autonomic parameters were measured. RESULTS:Mean arterial pressure decreased in both groups, the hypotensive response in group N+P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N+P than in group P. CONCLUSIONS: Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.
RCT Entities:
OBJECTIVE: Decrease in arterial blood pressure is a prominent adverse reaction during propofol (Disoprivan; AstraZeneca K.K., Osaka, Japan) sedation. The purpose of this prospective randomized study was to explore the effects of nitrous oxide (N2O) on the hypotensive response during propofol sedation. STUDY DESIGN: Twenty-six healthy volunteers received intravenous sedation with propofol alone (group P, n=13) or a combined technique using 20% N2O and propofol (group N+P, n=13). Propofol was administered by a target-controlled infusion system to attain and maintain a plasma propofol concentration of 1.5μg/mL. Hemodynamic and autonomic parameters were measured. RESULTS: Mean arterial pressure decreased in both groups, the hypotensive response in group N+P being significantly smaller than in group P. Reduction in the low-frequency power of systolic blood pressure variability, indicative of sympathetic nervous activity, was also smaller in group N+P than in group P. CONCLUSIONS: Addition of N2O to propofol sedation can attenuate the hypotensive effect of propofol.
Authors: Mohammad Fazel Bakhsheshi; Mamadou Diop; Laura B Morrison; Keith St Lawrence; Ting-Yim Lee Journal: Neurophotonics Date: 2015-09-21 Impact factor: 3.593