Literature DB >> 23740977

MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163.

Li Gao1, Xue-kun Guo, Lianghai Wang, Qiong Zhang, Ning Li, Xin-xin Chen, Yongqiang Wang, Wen-hai Feng.   

Abstract

We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by directly targeting its genomic RNA. Here, we report that miR-181 can downregulate the PRRSV receptor CD163 in blood monocytes and porcine alveolar macrophages (PAMs) through targeting the 3' untranslated region (UTR) of CD163 mRNA. Downregulation of CD163 leads to the inhibition of PRRSV entry into PAMs and subsequently suppresses PRRSV infection. Our findings indicate that delivery of miR-181 can be used as antiviral therapy against PRRSV infection.

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Year:  2013        PMID： 23740977      PMCID： PMC3719804          DOI： 10.1128/JVI.00718-13

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

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Journal:  J Immunol       Date:  1999-05-01       Impact factor: 5.422

2.  Granulocyte/macrophage colony-stimulating factor is expressed and secreted in cultures of murine L929 cells.

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Journal:  J Immunol Methods       Date:  1995-08-18       Impact factor: 2.303

3.  A cellular microRNA mediates antiviral defense in human cells.

Authors:  Charles-Henri Lecellier; Patrice Dunoyer; Khalil Arar; Jacqueline Lehmann-Che; Stephanie Eyquem; Christophe Himber; Ali Saïb; Olivier Voinnet
Journal:  Science       Date:  2005-04-22       Impact factor: 47.728

4.  Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection.

Authors:  Xue-kun Guo; Qiong Zhang; Li Gao; Ning Li; Xin-xin Chen; Wen-hai Feng
Journal:  J Virol       Date:  2012-11-14       Impact factor: 5.103

5.  CD163 expression confers susceptibility to porcine reproductive and respiratory syndrome viruses.

Authors:  Jay G Calvert; David E Slade; Shelly L Shields; Rika Jolie; Ramasamy M Mannan; Robert G Ankenbauer; Siao-Kun W Welch
Journal:  J Virol       Date:  2007-05-09       Impact factor: 5.103

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Journal:  Immunity       Date:  2007-07-05       Impact factor: 31.745

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Authors:  Kegong Tian; Xiuling Yu; Tiezhu Zhao; Youjun Feng; Zhen Cao; Chuanbin Wang; Yan Hu; Xizhao Chen; Dongmei Hu; Xinsheng Tian; Di Liu; Shuo Zhang; Xiaoyu Deng; Yinqiao Ding; Lu Yang; Yunxia Zhang; Haixia Xiao; Mingming Qiao; Bin Wang; Lili Hou; Xiaoying Wang; Xinyan Yang; Liping Kang; Ming Sun; Ping Jin; Shujuan Wang; Yoshihiro Kitamura; Jinghua Yan; George F Gao
Journal:  PLoS One       Date:  2007-06-13       Impact factor: 3.240

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Review 9.  Nidovirales: evolving the largest RNA virus genome.

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10.  Effects of origin and state of differentiation and activation of monocytes/macrophages on their susceptibility to porcine reproductive and respiratory syndrome virus (PRRSV).

Authors:  X Duan; H J Nauwynck; M B Pensaert
Journal:  Arch Virol       Date:  1997       Impact factor: 2.574
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  35 in total

1.  MicroRNA transcriptome analysis of poly I:C-stimulated and PRRSV-infected porcine alveolar macrophages.

Authors:  Junjing Wu; Ziyun Ji; Mu Qiao; Xianwen Peng; Huayu Wu; Zhongxu Song; Haizhong Zhao; Guisheng Liu; Fenge Li; Shuqi Mei
Journal:  J Appl Genet       Date:  2019-06-22       Impact factor: 3.240

2.  MicroRNA miR-24-3p promotes porcine reproductive and respiratory syndrome virus replication through suppression of heme oxygenase-1 expression.

Authors:  Shuqi Xiao; Xue Wang; Huaibao Ni; Na Li; Angke Zhang; Hongliang Liu; Fengxing Pu; Lele Xu; Jiming Gao; Qin Zhao; Yang Mu; Chengbao Wang; Yani Sun; Taofeng Du; Xingang Xu; Gaiping Zhang; Julian A Hiscox; Ian G Goodfellow; En-Min Zhou
Journal:  J Virol       Date:  2015-02-04       Impact factor: 5.103

3.  Host Cells Actively Resist Porcine Reproductive and Respiratory Syndrome Virus Infection via the IRF8-MicroRNA-10a-SRP14 Regulatory Pathway.

Authors:  Zifang Zheng; Xiali Fu; Xue Ling; Huanhuan Sun; Yang Li; Zhiqian Ma; Bingjie Wei; Haixue Zheng; Shuqi Xiao
Journal:  J Virol       Date:  2022-03-16       Impact factor: 6.549

4.  MicroRNA-376b-3p Promotes Porcine Reproductive and Respiratory Syndrome Virus Replication by Targeting Viral Restriction Factor TRIM22.

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Journal:  J Virol       Date:  2021-11-10       Impact factor: 6.549

5.  MiR-506 inhibits PRRSV replication in MARC-145 cells via CD151.

Authors:  Junjing Wu; Xianwen Peng; Ao Zhou; Mu Qiao; Huayu Wu; Hongwei Xiao; Guisheng Liu; Xinmin Zheng; Shujun Zhang; Shuqi Mei
Journal:  Mol Cell Biochem       Date:  2014-05-31       Impact factor: 3.396

6.  MicroRNA expression profiling in alveolar macrophages of indigenous Chinese Tongcheng pigs infected with PRRSV in vivo.

Authors:  Xiang Zhou; Jennifer J Michal; Zhihua Jiang; Bang Liu
Journal:  J Appl Genet       Date:  2017-10-02       Impact factor: 3.240

7.  Goat AKAP12: Indel Mutation Detection, Association Analysis With Litter Size and Alternative Splicing Variant Expression.

Authors:  Zihong Kang; Yangyang Bai; Xianyong Lan; Haiyu Zhao
Journal:  Front Genet       Date:  2021-05-21       Impact factor: 4.599

8.  Two Virus-Induced MicroRNAs Known Only from Teleost Fishes Are Orthologues of MicroRNAs Involved in Cell Cycle Control in Humans.

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Journal:  PLoS One       Date:  2015-07-24       Impact factor: 3.240

9.  Enforced expression of microRNA-21 influences the replication of varicella-zoster virus by triggering signal transducer and activator of transcription 3.

Authors:  Yan Li; Rina Wu; Zhongrong Liu; Jianyong Fan; Huilan Yang
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10.  Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection.

Authors:  Chengmin Wang; Yanyu Zhang; Jing Luo; Hua Ding; Shelan Liu; Said Amer; Li Xie; Wenting Lyv; Wen Su; Meng Li; Qinmiao Sun; Jiayin Dai; Hongxuan He
Journal:  Sci Rep       Date:  2016-04-27       Impact factor: 4.379
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