BACKGROUND: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. METHODS: Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. RESULTS: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5%) had breast reconstruction after prophylactic mastectomy. A total of 58.7% of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6% of women 35 years of age or younger [odds ratio (OR) 0.36, 95% confidence interval (CI) 0.26-0.50, p < 0.001]. In addition, 62.9% of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7% of women without a previous breast cancer diagnosis (OR 0.48, 95% CI 0.38-0.61, p < 0.001). A total of 66.9% of women from Canada had breast reconstruction after mastectomy compared to 71.9% of American women (OR 0.75, 95% CI 0.59-0.96, p = 0.02). CONCLUSIONS: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.
BACKGROUND: Breast reconstruction is an option for women with BRCA1 or BRCA2 mutations who elect to undergo prophylactic mastectomy to prevent breast cancer. We report on the uptake of breast reconstruction after prophylactic mastectomy in women with BRCA mutations from eight countries. METHODS:Women with a BRCA1 or BRCA2 mutation were questioned regarding their cancer preventive practices. Information was recorded on prophylactic mastectomy and breast reconstruction. RESULTS: A total of 1,635 women with a BRCA1 or BRCA2 mutation who elected to undergo prophylactic mastectomy from eight countries were included. A total of 1,137 women (69.5%) had breast reconstruction after prophylactic mastectomy. A total of 58.7% of women over the age of 45 years at the time of prophylactic mastectomy had breast reconstruction compared to 77.6% of women 35 years of age or younger [odds ratio (OR) 0.36, 95% confidence interval (CI) 0.26-0.50, p < 0.001]. In addition, 62.9% of women with a breast cancer diagnosis (contralateral prophylactic mastectomy) had breast reconstruction after prophylactic mastectomy compared to 79.7% of women without a previous breast cancer diagnosis (OR 0.48, 95% CI 0.38-0.61, p < 0.001). A total of 66.9% of women from Canada had breast reconstruction after mastectomy compared to 71.9% of American women (OR 0.75, 95% CI 0.59-0.96, p = 0.02). CONCLUSIONS: The majority of women elect for breast reconstruction after prophylactic mastectomy. However, younger women and those without a previous diagnosis of breast cancer are more likely to have breast reconstruction than older women or those with a previous diagnosis of cancer.
Authors: Warren H Tseng; Thomas R Stevenson; Robert J Canter; Steven L Chen; Vijay P Khatri; Richard J Bold; Steve R Martinez Journal: Plast Reconstr Surg Date: 2010-12 Impact factor: 4.730
Authors: R Jeevan; D A Cromwell; J P Browne; M Trivella; J Pereira; C M Caddy; C Sheppard; J H P van der Meulen Journal: Eur J Surg Oncol Date: 2010-07-06 Impact factor: 4.424
Authors: Kelly A Metcalfe; Jan Lubinski; Parviz Ghadirian; Henry Lynch; Charmaine Kim-Sing; Eitan Friedman; William D Foulkes; Susan Domchek; Peter Ainsworth; Claudine Isaacs; Nadine Tung; Jacek Gronwald; Shelly Cummings; Teresa Wagner; Siranoush Manoukian; Pål Møller; Jeffrey Weitzel; Ping Sun; Steven A Narod Journal: J Clin Oncol Date: 2008-01-14 Impact factor: 44.544
Authors: Amy K Alderman; Sarah T Hawley; Nancy K Janz; Mahasin S Mujahid; Monica Morrow; Ann S Hamilton; John J Graff; Steven J Katz Journal: J Clin Oncol Date: 2009-10-05 Impact factor: 44.544
Authors: K Metcalfe; S Gershman; H T Lynch; P Ghadirian; N Tung; C Kim-Sing; O I Olopade; S Domchek; J McLennan; A Eisen; W D Foulkes; B Rosen; P Sun; S A Narod Journal: Br J Cancer Date: 2011-04-12 Impact factor: 7.640
Authors: Vivian J Hu; Sean P McCleary; Carolyn P Smullin; Ricardo Rosales Morales; Andrew L Da Lio Journal: Plast Reconstr Surg Glob Open Date: 2022-04-18
Authors: Stacey J Jones; Philip Turton; Rajgopal Achuthan; Brian V Hogan; Shireen N Mckenzie; Baek Kim Journal: Plast Reconstr Surg Glob Open Date: 2020-12-17