PURPOSE: To develop an efficient biocompatible and targeted drug delivery system in which platelets, an essential blood component having a natural affinity for cancer cells, are used as carrier of anticancer drug as delivery of drug to the targeted site is crucial for cancer treatment. METHODS: Doxorubicin hydrochloride, a potent anti cancer drug, was delivered in lung adenocarcinoma cell line (A549) using platelet as a delivery agent. This delivery mode was also tested in Ehrlich ascites carcinoma (EAC) bearing mice in presence and absence of platelets. RESULTS: The results show that platelets can uptake the drug and release the same upon activation. The efficiency of drug loaded platelets in inducing cytotoxicity was significantly higher in both in vitro and in vivo model, as compared to the free drug. CONCLUSIONS: The proposed drug delivery strategy may lead to clinical improvement in the management of cancer treatment as lower drug concentration can be used in a targeted mode. Additionally the method can be personalized as patient's own platelet can be used for deliver various drugs.
PURPOSE: To develop an efficient biocompatible and targeted drug delivery system in which platelets, an essential blood component having a natural affinity for cancer cells, are used as carrier of anticancer drug as delivery of drug to the targeted site is crucial for cancer treatment. METHODS:Doxorubicin hydrochloride, a potent anti cancer drug, was delivered in lung adenocarcinoma cell line (A549) using platelet as a delivery agent. This delivery mode was also tested in Ehrlich ascites carcinoma (EAC) bearing mice in presence and absence of platelets. RESULTS: The results show that platelets can uptake the drug and release the same upon activation. The efficiency of drug loaded platelets in inducing cytotoxicity was significantly higher in both in vitro and in vivo model, as compared to the free drug. CONCLUSIONS: The proposed drug delivery strategy may lead to clinical improvement in the management of cancer treatment as lower drug concentration can be used in a targeted mode. Additionally the method can be personalized as patient's own platelet can be used for deliver various drugs.
Authors: S Pal; T Choudhuri; S Chattopadhyay; A Bhattacharya; G K Datta; T Das; G Sa Journal: Biochem Biophys Res Commun Date: 2001-11-02 Impact factor: 3.575
Authors: Maluta S Mufamadi; Viness Pillay; Yahya E Choonara; Lisa C Du Toit; Girish Modi; Dinesh Naidoo; Valence M K Ndesendo Journal: J Drug Deliv Date: 2011-02-08
Authors: Ann-Kathrin Börger; Dorothee Eicke; Christina Wolf; Christiane Gras; Susanne Aufderbeck; Kai Schulze; Lena Engels; Britta Eiz-Vesper; Axel Schambach; Carlos A Guzman; Nico Lachmann; Thomas Moritz; Ulrich Martin; Rainer Blasczyk; Constança Figueiredo Journal: Mol Med Date: 2016-05-16 Impact factor: 6.354