Literature DB >> 23738443

Cytotoxicity of meroterpenoids from Sargassum siliquastrum against human cancer cells.

Jung Im Lee1, Myoung K Kwak, Hee Y Park, Youngwan Seo.   

Abstract

The cytotoxicity of the brown alga Sargassum siliquastrum on human cancer cells (AGS, HT-29, HT-1080, and MCF-7) was investigated. Bioassay-guided fractionation of the crude extracts showed that the 85% aq. methanol (MeOH) fraction was the most toxic. Seven known meroterpenoids (1-7) were isolated from this cytotoxic fraction. Each compound was evaluated for its cytotoxic effect on human cancer cells. Compounds 1, 2, and 4 showed strong cytotoxicity against AGS, HT-29, and HT-1080 cell lines, with IC50 values ranging from 0.5 to 5.7 microg/mL.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23738443

Source DB:  PubMed          Journal:  Nat Prod Commun        ISSN： 1555-9475            Impact factor:   0.986


  4 in total

Review 1.  Biological activities of meroterpenoids isolated from different sources.

Authors:  Neeraj Kumar Fuloria; Radhika K Raheja; Kaushal H Shah; Manisha J Oza; Yogesh A Kulkarni; Vetriselvan Subramaniyan; Mahendran Sekar; Shivkanya Fuloria
Journal:  Front Pharmacol       Date:  2022-09-19       Impact factor: 5.988

2.  Ethanol Extract of Sargassum siliquastrum Inhibits Lipopolysaccharide-Induced Nitric Oxide Generation by Downregulating the Nuclear Factor-Kappa B Signaling Pathway.

Authors:  Hye-Young Min; Hyewon Kim; Ho Jin Lee; Na-Young Yoon; Yeon-Kye Kim; Ho-Young Lee
Journal:  Evid Based Complement Alternat Med       Date:  2022-06-10       Impact factor: 2.650

3.  Crude extract and solvent fractions of Calystegia soldanella induce G1 and S phase arrest of the cell cycle in HepG2 cells.

Authors:  Jung Im Lee; In-Hye Kim; Taek-Jeong Nam
Journal:  Int J Oncol       Date:  2017-01-02       Impact factor: 5.650

Review 4.  Pharmacological and natural products diversity of the brown algae genus Sargassum.

Authors:  Mohammed I Rushdi; Iman A M Abdel-Rahman; Hani Saber; Eman Zekry Attia; Wedad M Abdelraheem; Hashem A Madkour; Hossam M Hassan; Abeer H Elmaidomy; Usama Ramadan Abdelmohsen
Journal:  RSC Adv       Date:  2020-07-01       Impact factor: 4.036
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.