BACKGROUND: Angiogenesis is likely critical for the process of intramembranous osteogenesis; however, the developmental relationship between blood vessels and bone mineralization is not well studied within intramembranous bones. Given its importance, changes in angiogenesis regulation are likely to contribute to evolutionarily and medically relevant craniofacial variation. RESULTS: We summarize what is known about the association between angiogenesis and intramembranous osteogenesis, supplementing with information from the better-studied processes of endochondral ossification and distraction osteogenesis. Based on this review, we introduce a model of angiogenesis during early intramembranous osteogenesis as well as a series of null hypotheses to be tested. CONCLUSIONS: This model can serve as a basis of future research on the spatio-temporal association and regulatory interactions of mesenchymal, vascular, and bone cells, which will be required to illuminate the potential effects of angiogenesis dysregulation on craniofacial skeletal phenotypes.
BACKGROUND: Angiogenesis is likely critical for the process of intramembranous osteogenesis; however, the developmental relationship between blood vessels and bone mineralization is not well studied within intramembranous bones. Given its importance, changes in angiogenesis regulation are likely to contribute to evolutionarily and medically relevant craniofacial variation. RESULTS: We summarize what is known about the association between angiogenesis and intramembranous osteogenesis, supplementing with information from the better-studied processes of endochondral ossification and distraction osteogenesis. Based on this review, we introduce a model of angiogenesis during early intramembranous osteogenesis as well as a series of null hypotheses to be tested. CONCLUSIONS: This model can serve as a basis of future research on the spatio-temporal association and regulatory interactions of mesenchymal, vascular, and bone cells, which will be required to illuminate the potential effects of angiogenesis dysregulation on craniofacial skeletal phenotypes.
Authors: Christa Maes; Tatsuya Kobayashi; Martin K Selig; Sophie Torrekens; Sanford I Roth; Susan Mackem; Geert Carmeliet; Henry M Kronenberg Journal: Dev Cell Date: 2010-08-17 Impact factor: 12.270
Authors: Bao-Ngoc B Nguyen; Rebecca A Moriarty; Tim Kamalitdinov; Julie M Etheridge; John P Fisher Journal: J Biomed Mater Res A Date: 2017-02-02 Impact factor: 4.396
Authors: Arda Cetinkaya; Jingwei Rachel Xiong; İbrahim Vargel; Kemal Kösemehmetoğlu; Halil İbrahim Canter; Ömer Faruk Gerdan; Nicola Longo; Ahmad Alzahrani; Mireia Perez Camps; Ekim Zihni Taskiran; Simone Laupheimer; Lorenzo D Botto; Eeswari Paramalingam; Zeliha Gormez; Elif Uz; Bayram Yuksel; Şevket Ruacan; Mahmut Şamil Sağıroğlu; Tokiharu Takahashi; Bruno Reversade; Nurten Ayse Akarsu Journal: Am J Hum Genet Date: 2016-07-28 Impact factor: 11.025
Authors: Shunsuke Yamada; Mary C Wallingford; Suhaib Borgeia; Timothy C Cox; Cecilia M Giachelli Journal: Biochem Biophys Res Commun Date: 2017-11-11 Impact factor: 3.575
Authors: Eric Van Otterloo; Weiguo Feng; Kenneth L Jones; Nancy E Hynes; David E Clouthier; Lee Niswander; Trevor Williams Journal: Dev Biol Date: 2015-12-31 Impact factor: 3.582