AIMS: Cholinesterase inhibitors (ChEIs) are used for symptomatic treatment of Alzheimer's disease. These drugs have vagotonic and anti-inflammatory properties that could be of interest also with respect to cardiovascular disease. This study evaluated the use of ChEIs and the later risk of myocardial infarction and death. METHODS AND RESULTS: The cohort consisted of 7073 subjects (mean age 79 years) from the Swedish Dementia Registry with the diagnoses of Alzheimer's dementia or Alzheimer's mixed dementia since 2007. Cholinesterase inhibitor use was linked to diagnosed myocardial infarctions (MIs) and death using national registers. During a mean follow-up period of 503 (range 0-2009) days, 831 subjects in the cohort suffered MI or died. After adjustment for confounders, subjects who used ChEIs had a 34% lower risk for this composite endpoint during the follow-up than those who did not [hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.56-0.78]. Cholinesterase inhibitor use was also associated with a lower risk of death (HR: 0.64, 95% CI: 0.54-0.76) and MI (HR: 0.62, 95% CI: 0.40-0.95) when analysed separately. Subjects taking the highest recommended ChEI doses (donepezil 10 mg, rivastigmine >6 mg, galantamine 24 mg) had the lowest risk of MI (HR: 0.35, 95% CI: 0.19-0.64), or death (HR: 0.54, 95% CI: 0.43-0.67) compared with those who had never used ChEIs. CONCLUSION: Cholinesterase inhibitor use was associated with a reduced risk of MI and death in a nationwide cohort of subjects diagnosed with Alzheimer's dementia. These associations were stronger with increasing ChEI dose.
AIMS: Cholinesterase inhibitors (ChEIs) are used for symptomatic treatment of Alzheimer's disease. These drugs have vagotonic and anti-inflammatory properties that could be of interest also with respect to cardiovascular disease. This study evaluated the use of ChEIs and the later risk of myocardial infarction and death. METHODS AND RESULTS: The cohort consisted of 7073 subjects (mean age 79 years) from the Swedish Dementia Registry with the diagnoses of Alzheimer's dementia or Alzheimer's mixed dementia since 2007. Cholinesterase inhibitor use was linked to diagnosed myocardial infarctions (MIs) and death using national registers. During a mean follow-up period of 503 (range 0-2009) days, 831 subjects in the cohort suffered MI or died. After adjustment for confounders, subjects who used ChEIs had a 34% lower risk for this composite endpoint during the follow-up than those who did not [hazard ratio (HR) 0.66, 95% confidence interval (CI) 0.56-0.78]. Cholinesterase inhibitor use was also associated with a lower risk of death (HR: 0.64, 95% CI: 0.54-0.76) and MI (HR: 0.62, 95% CI: 0.40-0.95) when analysed separately. Subjects taking the highest recommended ChEI doses (donepezil 10 mg, rivastigmine >6 mg, galantamine 24 mg) had the lowest risk of MI (HR: 0.35, 95% CI: 0.19-0.64), or death (HR: 0.54, 95% CI: 0.43-0.67) compared with those who had never used ChEIs. CONCLUSION:Cholinesterase inhibitor use was associated with a reduced risk of MI and death in a nationwide cohort of subjects diagnosed with Alzheimer's dementia. These associations were stronger with increasing ChEI dose.
Authors: Ashbeel Roy; Mouhamed Dakroub; Geisa C S V Tezini; Yin Liu; Silvia Guatimosim; Qingping Feng; Helio C Salgado; Vania F Prado; Marco A M Prado; Robert Gros Journal: FASEB J Date: 2015-10-19 Impact factor: 5.191
Authors: Alberto Pilotto; Maria Cristina Polidori; Nicola Veronese; Francesco Panza; Rosa Arboretti Giancristofaro; Andrea Pilotto; Julia Daragjati; Eleonora Carrozzo; Camilla Prete; Pietro Gallina; Alessandro Padovani; Stefania Maggi Journal: J Am Med Dir Assoc Date: 2017-10-12 Impact factor: 4.669
Authors: Spyros A Mavropoulos; Nayaab S Khan; Asaph C J Levy; Bradley T Faliks; Cristina P Sison; Valentin A Pavlov; Youhua Zhang; Kaie Ojamaa Journal: Mol Med Date: 2017-06-08 Impact factor: 6.354
Authors: Cibele Rocha-Resende; Carla Weinheimer; Geetika Bajpai; Luigi Adamo; Scot J Matkovich; Joel Schilling; Philip M Barger; Kory J Lavine; Douglas L Mann Journal: JCI Insight Date: 2019-06-04
Authors: Fernanda M Consolim-Colombo; Carine T Sangaleti; Fernando O Costa; Tercio L Morais; Heno F Lopes; Josiane M Motta; Maria C Irigoyen; Luiz A Bortoloto; Carlos Eduardo Rochitte; Yael Tobi Harris; Sanjaya K Satapathy; Peder S Olofsson; Meredith Akerman; Sangeeta S Chavan; Meggan MacKay; Douglas P Barnaby; Martin L Lesser; Jesse Roth; Kevin J Tracey; Valentin A Pavlov Journal: JCI Insight Date: 2017-07-20