OBJECTIVES: Suicide is a significant cause of mortality in patients with major affective disorders (MAD), and suicidal behavior and MAD co-aggregate in families. However, the transmission of suicidal behavior is partially independent from that of MAD. We analyzed the lifetime prevalence of completed and attempted suicides in a large sample of families with bipolar disorder (BD), its relation to family history of MAD and BD, and the contribution of clinical and treatment factors to the risk of suicidal behavior. METHODS: We studied 737 families of probands with MAD with 4919 first-degree relatives (818 affected, 3948 unaffected, and 153 subjects with no information available). Lifetime psychiatric diagnoses and suicidal behavior in first-degree relatives were assessed using semi-structured interviews, family history methods, and reviews of clinical records. Cox proportional hazard and logistic regression models were used to investigate the role of clinical covariates in the risk of suicidal behavior, and in the prevalence of MAD and BD. RESULTS: The estimated lifetime prevalence of suicidal behavior (attempted and completed suicides) in 737 probands was 38.4 ± 3.0%. Lithium treatment decreased suicide risk in probands (p = 0.007). In first-degree relatives, a family history of suicidal behavior contributed significantly to the joint risk of MAD and suicidal behavior (p = 0.0006). CONCLUSIONS: The liability to suicidal behavior is influenced by genetic factors (particularly family history of suicidal behavior and MAD). Even in the presence of high genetic risk for suicidal behavior, lithium treatment decreases suicide rates significantly.
OBJECTIVES: Suicide is a significant cause of mortality in patients with major affective disorders (MAD), and suicidal behavior and MAD co-aggregate in families. However, the transmission of suicidal behavior is partially independent from that of MAD. We analyzed the lifetime prevalence of completed and attempted suicides in a large sample of families with bipolar disorder (BD), its relation to family history of MAD and BD, and the contribution of clinical and treatment factors to the risk of suicidal behavior. METHODS: We studied 737 families of probands with MAD with 4919 first-degree relatives (818 affected, 3948 unaffected, and 153 subjects with no information available). Lifetime psychiatric diagnoses and suicidal behavior in first-degree relatives were assessed using semi-structured interviews, family history methods, and reviews of clinical records. Cox proportional hazard and logistic regression models were used to investigate the role of clinical covariates in the risk of suicidal behavior, and in the prevalence of MAD and BD. RESULTS: The estimated lifetime prevalence of suicidal behavior (attempted and completed suicides) in 737 probands was 38.4 ± 3.0%. Lithium treatment decreased suicide risk in probands (p = 0.007). In first-degree relatives, a family history of suicidal behavior contributed significantly to the joint risk of MAD and suicidal behavior (p = 0.0006). CONCLUSIONS: The liability to suicidal behavior is influenced by genetic factors (particularly family history of suicidal behavior and MAD). Even in the presence of high genetic risk for suicidal behavior, lithium treatment decreases suicide rates significantly.
Authors: Ayal Schaffer; Erkki T Isometsä; Jean-Michel Azorin; Frederick Cassidy; Tina Goldstein; Zoltán Rihmer; Mark Sinyor; Leonardo Tondo; Doris H Moreno; Gustavo Turecki; Catherine Reis; Lars Vedel Kessing; Kyooseob Ha; Abraham Weizman; Annette Beautrais; Yuan-Hwa Chou; Nancy Diazgranados; Anthony J Levitt; Carlos A Zarate; Lakshmi Yatham Journal: Aust N Z J Psychiatry Date: 2015-07-14 Impact factor: 5.744
Authors: Ayal Schaffer; Erkki T Isometsä; Leonardo Tondo; Doris H Moreno; Gustavo Turecki; Catherine Reis; Frederick Cassidy; Mark Sinyor; Jean-Michel Azorin; Lars Vedel Kessing; Kyooseob Ha; Tina Goldstein; Abraham Weizman; Annette Beautrais; Yuan-Hwa Chou; Nancy Diazgranados; Anthony J Levitt; Carlos A Zarate; Zoltán Rihmer; Lakshmi N Yatham Journal: Bipolar Disord Date: 2014-10-20 Impact factor: 6.744
Authors: Roger S McIntyre; Martin Alda; Ross J Baldessarini; Michael Bauer; Michael Berk; Christoph U Correll; Andrea Fagiolini; Kostas Fountoulakis; Mark A Frye; Heinz Grunze; Lars V Kessing; David J Miklowitz; Gordon Parker; Robert M Post; Alan C Swann; Trisha Suppes; Eduard Vieta; Allan Young; Mario Maj Journal: World Psychiatry Date: 2022-10 Impact factor: 79.683
Authors: Leonardo Tondo; Martin Alda; Michael Bauer; Veerle Bergink; Paul Grof; Tomas Hajek; Ute Lewitka; Rasmus W Licht; Mirko Manchia; Bruno Müller-Oerlinghausen; René E Nielsen; Marylou Selo; Christian Simhandl; Ross J Baldessarini Journal: Int J Bipolar Disord Date: 2019-07-22
Authors: Andrea Murru; Mirko Manchia; Tomas Hajek; René E Nielsen; Janusz K Rybakowski; Gabriele Sani; Thomas G Schulze; Leonardo Tondo; Michael Bauer Journal: Int J Bipolar Disord Date: 2020-05-20
Authors: Abraham Nunes; William Stone; Raffaella Ardau; Anne Berghöfer; Alberto Bocchetta; Caterina Chillotti; Valeria Deiana; Franziska Degenhardt; Andreas J Forstner; Julie S Garnham; Eva Grof; Tomas Hajek; Mirko Manchia; Manuel Mattheisen; Francis McMahon; Bruno Müller-Oerlinghausen; Markus M Nöthen; Marco Pinna; Claudia Pisanu; Claire O'Donovan; Marcella D C Rietschel; Guy Rouleau; Thomas Schulze; Giovanni Severino; Claire M Slaney; Alessio Squassina; Aleksandra Suwalska; Gustavo Turecki; Rudolf Uher; Petr Zvolsky; Pablo Cervantes; Maria Del Zompo; Paul Grof; Janusz Rybakowski; Leonardo Tondo; Thomas Trappenberg; Martin Alda Journal: Transl Psychiatry Date: 2021-01-11 Impact factor: 6.222
Authors: William Stone; Abraham Nunes; Kazufumi Akiyama; Nirmala Akula; Raffaella Ardau; Jean-Michel Aubry; Lena Backlund; Michael Bauer; Frank Bellivier; Pablo Cervantes; Hsi-Chung Chen; Caterina Chillotti; Cristiana Cruceanu; Alexandre Dayer; Franziska Degenhardt; Maria Del Zompo; Andreas J Forstner; Mark Frye; Janice M Fullerton; Maria Grigoroiu-Serbanescu; Paul Grof; Ryota Hashimoto; Liping Hou; Esther Jiménez; Tadafumi Kato; John Kelsoe; Sarah Kittel-Schneider; Po-Hsiu Kuo; Ichiro Kusumi; Catharina Lavebratt; Mirko Manchia; Lina Martinsson; Manuel Mattheisen; Francis J McMahon; Vincent Millischer; Philip B Mitchell; Markus M Nöthen; Claire O'Donovan; Norio Ozaki; Claudia Pisanu; Andreas Reif; Marcella Rietschel; Guy Rouleau; Janusz Rybakowski; Martin Schalling; Peter R Schofield; Thomas G Schulze; Giovanni Severino; Alessio Squassina; Julia Veeh; Eduard Vieta; Thomas Trappenberg; Martin Alda Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379