Literature DB >> 23734684

Manipulation of autophagy in cancer cells: an innovative strategy to fight drug resistance.

Francesca Aredia1, A Ivana Scovassi.   

Abstract

Autophagy is a catabolic process activated by stress conditions and nutrient deprivation, to which it reacts by promoting the degradation of damaged organelles and misfolded/aggregated proteins, as well as generating new energetic pools. Paradoxically, in cancer cells, which signal the dangerous microenvironment occurring during clinical therapies, autophagy could promote their proliferation and sustain drug resistance. Special attention is given to autophagy manipulation in order to counteract drug resistance of cancer cells. This article describes the basic properties of autophagy and focuses on the strategies of manipulating it.

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Year:  2013        PMID： 23734684     DOI： 10.4155/fmc.13.85

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


  10 in total

Review 1.  Drug Resistance in Colorectal Cancer: From Mechanism to Clinic.

Authors:  Qianyu Wang; Xiaofei Shen; Gang Chen; Junfeng Du
Journal:  Cancers (Basel)       Date:  2022-06-14       Impact factor: 6.575

2.  Adenine causes cell cycle arrest and autophagy of chronic myelogenous leukemia K562 cells via AMP-activated protein kinase signaling.

Authors:  San-Yuan Chen; Chun-Hsiang Lin; Jiun-Tsai Lin; Yi-Fang Cheng; Han-Min Chen; Shao-Hsuan Kao
Journal:  Oncol Lett       Date:  2017-09-06       Impact factor: 2.967

3.  Induction of autophagy in human neuroblastoma SH-SY5Y cells by tri-ortho-cresyl phosphate.

Authors:  Ding-Xin Long; Dan Hu; Pan Wang; Yi-Jun Wu
Journal:  Mol Cell Biochem       Date:  2014-07-03       Impact factor: 3.396

4.  Glutathione S-transferases P1 protects breast cancer cell from adriamycin-induced cell death through promoting autophagy.

Authors:  Xiaoliang Dong; Yang Yang; Yi Zhou; Xiaowen Bi; Ningwei Zhao; Zhengping Zhang; Ling Li; Qiyun Hang; Ruhui Zhang; Dan Chen; Peng Cao; Zhimin Yin; Lan Luo
Journal:  Cell Death Differ       Date:  2019-01-25       Impact factor: 15.828

5.  IBP-mediated suppression of autophagy promotes growth and metastasis of breast cancer cells via activating mTORC2/Akt/FOXO3a signaling pathway.

Authors:  S Chen; Q Han; X Wang; M Yang; Z Zhang; P Li; A Chen; C Hu; S Li
Journal:  Cell Death Dis       Date:  2013-10-10       Impact factor: 8.469

6.  MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin.

Authors:  Zhiyu Wang; Neng Wang; Pengxi Liu; Qianjun Chen; Honglin Situ; Ting Xie; Jianxing Zhang; Cheng Peng; Yi Lin; Jianping Chen
Journal:  Oncotarget       Date:  2014-08-30

Review 7.  Role of autophagy in tumorigenesis, metastasis, targeted therapy and drug resistance of hepatocellular carcinoma.

Authors:  Fang Huang; Bing-Rong Wang; Yi-Gang Wang
Journal:  World J Gastroenterol       Date:  2018-11-07       Impact factor: 5.742

8.  Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7.

Authors:  Xufeng Pan; Yong Chen; Yuzhou Shen; Jicheng Tantai
Journal:  Cell Death Dis       Date:  2019-06-03       Impact factor: 8.469

Review 9.  Autophagy Regulation by Crosstalk between miRNAs and Ubiquitination System.

Authors:  Junyan Qu; Zhenghong Lin
Journal:  Int J Mol Sci       Date:  2021-11-03       Impact factor: 5.923

10.  ARHI (DIRAS3)-mediated autophagy-associated cell death enhances chemosensitivity to cisplatin in ovarian cancer cell lines and xenografts.

Authors:  M N Washington; G Suh; A F Orozco; M N Sutton; H Yang; Y Wang; W Mao; S Millward; A Ornelas; N Atkinson; W Liao; R C Bast; Z Lu
Journal:  Cell Death Dis       Date:  2015-08-06       Impact factor: 8.469
  10 in total

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