Literature DB >> 23734560

One-pot synthesis of hypervalent iodine reagents for electrophilic trifluoromethylation.

Václav Matoušek1, Ewa Pietrasiak, Rino Schwenk, Antonio Togni.   

Abstract

Simplified syntheses suited for large scale preparations of the two hypervalent iodine reagents 1 and 2 for electrophilic trifluoromethylation are reported. In both cases, the stoichiometric oxidants sodium metaperiodate and tert-butyl hypochlorite have been replaced by trichloroisocyanuric acid. Reagent 1 is accessible in a one-pot procedure from 2-iodobenzoic acid in 72% yield. Reagent 2 was prepared via fluoroiodane 11 in a considerably shorter reaction time and with no need of an accurate temperature control.

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Year:  2013        PMID： 23734560     DOI： 10.1021/jo400774u

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  17 in total

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