BACKGROUND: Serum gentamicin concentrations (GSCs) are frequently obtained before and after gentamicin administration to newborns with, or at high risk for, sepsis. OBJECTIVE: To determine whether performing a peak GSC assay when the trough GSC is within the guidelines for care would add clinically relevant information for health care workers. METHODS: A retrospective review of the IWK Health Centre (Halifax, Nova Scotia) laboratory database for peak and trough GSC for infants <28 days after birth was performed. RESULTS: Of 5253 paired samples of trough and peak GSCs, 3001 (57%) had trough GSCs ≤2 μg/mL. Of these, only nine (0.3%) had a peak GSC >10 μg/mL. CONCLUSIONS: Performing a peak GSC measurement does not provide further clinically important data and increases patient morbidity and hospital costs.
BACKGROUND: Serum gentamicin concentrations (GSCs) are frequently obtained before and after gentamicin administration to newborns with, or at high risk for, sepsis. OBJECTIVE: To determine whether performing a peak GSC assay when the trough GSC is within the guidelines for care would add clinically relevant information for health care workers. METHODS: A retrospective review of the IWK Health Centre (Halifax, Nova Scotia) laboratory database for peak and trough GSC for infants <28 days after birth was performed. RESULTS: Of 5253 paired samples of trough and peak GSCs, 3001 (57%) had trough GSCs ≤2 μg/mL. Of these, only nine (0.3%) had a peak GSC >10 μg/mL. CONCLUSIONS: Performing a peak GSC measurement does not provide further clinically important data and increases patient morbidity and hospital costs.
Authors: Stephanie J Schrag; James L Hadler; Kathryn E Arnold; Patricia Martell-Cleary; Arthur Reingold; Anne Schuchat Journal: Pediatrics Date: 2006-08 Impact factor: 7.124
Authors: David S Hoff; Roger A Wilcox; Lisa M Tollefson; Polina G Lipnik; Amy R Commers; Meixia Liu Journal: Pharmacotherapy Date: 2009-11 Impact factor: 4.705
Authors: J Ibrahim; D Maffei; G El-Chaar; S Islam; S Ponnaiya; A Nayak; W Rosenfeld; N Hanna Journal: J Perinatol Date: 2016-08-18 Impact factor: 2.521