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Literature DB >> 23728464

YAP forces fibroblasts to feel the tension.

Ori Maller, Christopher C DuFort, Valerie M Weaver.

Abstract

Cancer-associated fibroblasts (CAFs) may contribute to tissue tension and cancer progression by increasing extracellular matrix (ECM) deposition and remodelling. However, how CAFs become activated and their roles in tumour mechanics have remained unclear. YAP is now identified as a tension-stimulated CAF activator that promotes malignancy through a mechanically reinforced feed-forward loop.

Entities: Disease Gene

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Year: 2013 PMID： 23728464 DOI： 10.1038/ncb2777

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

15 in total

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