INTRODUCTION: Panton-Valentine leukocidin (PVL) is a toxin associated with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide and also occurs in community-associated methicillin-susceptible S aureus (CA-MSSA) strains. The aims of the study were to determine the prevalence of PVL in community-onset S aureus skin and soft-tissue infections (SSTIs) and to analyse the influence of methicillin resistance and PVL presence on the clinical characteristics of these infections. PATIENTS AND METHODS: We prospectively enrolled all children with S aureus community-onset SSTIs attending the emergency department of a tertiary hospital between 2007 and 2009. Results A total of 142 S aureus SSTIs were identified, 46 (32%) were PVL positive. The proportion of subjects in each group was: 89 (63%) PVL-MSSA, 33 (23%) PVL+MSSA, 13 (9%) PVL+MRSA and 7 (5%) PVL-MRSA. PVL+infections were more frequently abscesses (63% vs 39%, p<0.01), and more often required incision and drainage (p<0.01) and hospital admission (46% vs 26%, p=0.02). MRSA infections were also more frequently associated with abscesses but in a multivariable analysis only PVL remained independently related (OR 2.33; 95% CI 1.10 to 4.90). CONCLUSIONS: Our study found a high prevalence of PVL presence in community-onset S aureus SSTIs in children in Spain. This toxin is associated with more abscess formation, regardless of methicillin resistance.
INTRODUCTION: Panton-Valentine leukocidin (PVL) is a toxin associated with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) worldwide and also occurs in community-associated methicillin-susceptible S aureus (CA-MSSA) strains. The aims of the study were to determine the prevalence of PVL in community-onset S aureus skin and soft-tissue infections (SSTIs) and to analyse the influence of methicillin resistance and PVL presence on the clinical characteristics of these infections. PATIENTS AND METHODS: We prospectively enrolled all children with S aureus community-onset SSTIs attending the emergency department of a tertiary hospital between 2007 and 2009. Results A total of 142 S aureus SSTIs were identified, 46 (32%) were PVL positive. The proportion of subjects in each group was: 89 (63%) PVL-MSSA, 33 (23%) PVL+MSSA, 13 (9%) PVL+MRSA and 7 (5%) PVL-MRSA. PVL+infections were more frequently abscesses (63% vs 39%, p<0.01), and more often required incision and drainage (p<0.01) and hospital admission (46% vs 26%, p=0.02). MRSA infections were also more frequently associated with abscesses but in a multivariable analysis only PVL remained independently related (OR 2.33; 95% CI 1.10 to 4.90). CONCLUSIONS: Our study found a high prevalence of PVL presence in community-onset S aureus SSTIs in children in Spain. This toxin is associated with more abscess formation, regardless of methicillin resistance.
Authors: Sabrina Müller; Andrea J Wolf; Iliyan D Iliev; Bethany L Berg; David M Underhill; George Y Liu Journal: Cell Host Microbe Date: 2015-11-11 Impact factor: 21.023
Authors: Teresa Del Rosal; Ana Méndez-Echevarría; Cesar Garcia-Vera; Luis Escosa-Garcia; Martin Agud; Fernando Chaves; Federico Román; José Gutierrez-Fernandez; Enrique Ruiz de Gopegui; Guillermo Ruiz-Carrascoso; Maria Del Carmen Ruiz-Gallego; Albert Bernet; Sara Maria Quevedo; Ana Maria Fernández-Verdugo; Jesús Díez-Sebastian; Cristina Calvo Journal: Infect Drug Resist Date: 2020-12-23 Impact factor: 4.003
Authors: Federico Román; Ana Mendez-Echevarria; Teresa Del Rosal; Cesar Garcia-Vera; Luis Escosa-Garcia; Martin Agud; Fernando Chaves; José Gutiérrez-Fernández; Enrique Ruiz de Gopegui; Guillermo Ruiz-Carrascoso; Maria Del Carmen Ruiz-Gallego; Albert Bernet; Sara Maria Quevedo; Ana Maria Fernández-Verdugo; Talia Sainz; Cristina Calvo Journal: Microbiologyopen Date: 2021-10 Impact factor: 3.139