Literature DB >> 23727842

Functional dissection and module swapping of fungal cyclooligomer depsipeptide synthetases.

Dayu Yu1, Fuchao Xu, David Gage, Jixun Zhan.   

Abstract

BbBSLS and BbBEAS were dissected and reconstituted in Saccharomyces cerevisiae. The intermodular linker is essential for the reconstitution of the separate modules. Module 1 can be swapped between BbBEAS and BbBSLS, while modules 2 and 3 control the product profiles. BbBSLS is a flexible enzyme that also synthesizes beauvericins.

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Year:  2013        PMID： 23727842     DOI： 10.1039/c3cc42425a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

1.  Inter-Modular Linkers play a crucial role in governing the biosynthesis of non-ribosomal peptides.

Authors:  Sherif Farag; Rachel M Bleich; Elizabeth A Shank; Olexandr Isayev; Albert A Bowers; Alexander Tropsha
Journal:  Bioinformatics       Date:  2019-10-01       Impact factor: 6.937

2.  Molecular Cross-Talk between Nonribosomal Peptide Synthetase Carrier Proteins and Unstructured Linker Regions.

Authors:  Bradley J Harden; Dominique P Frueh
Journal:  Chembiochem       Date:  2017-02-22       Impact factor: 3.164

3.  Decoding and reprogramming fungal iterative nonribosomal peptide synthetases.

Authors:  Dayu Yu; Fuchao Xu; Shuwei Zhang; Jixun Zhan
Journal:  Nat Commun       Date:  2017-05-23       Impact factor: 14.919

4.  Aspergillus niger is a superior expression host for the production of bioactive fungal cyclodepsipeptides.

Authors:  Simon Boecker; Stefan Grätz; Dennis Kerwat; Lutz Adam; David Schirmer; Lennart Richter; Tabea Schütze; Daniel Petras; Roderich D Süssmuth; Vera Meyer
Journal:  Fungal Biol Biotechnol       Date:  2018-03-02

5.  Harnessing fungal nonribosomal cyclodepsipeptide synthetases for mechanistic insights and tailored engineering.

Authors:  Charlotte Steiniger; Sylvester Hoffmann; Andi Mainz; Marcel Kaiser; Kerstin Voigt; Vera Meyer; Roderich D Süssmuth
Journal:  Chem Sci       Date:  2017-09-25       Impact factor: 9.825

6.  Biochemical characterization of the Nocardia lactamdurans ACV synthetase.

Authors:  Riccardo Iacovelli; Reto D Zwahlen; Roel A L Bovenberg; Arnold J M Driessen
Journal:  PLoS One       Date:  2020-04-10       Impact factor: 3.240

7.  Modified substrate specificity of a methyltransferase domain by protein insertion into an adenylation domain of the bassianolide synthetase.

Authors:  Fuchao Xu; Russell Butler; Kyle May; Megi Rexhepaj; Dayu Yu; Jiachen Zi; Yi Chen; Yonghong Liang; Jia Zeng; Joan Hevel; Jixun Zhan
Journal:  J Biol Eng       Date:  2019-07-31       Impact factor: 4.355

Review 8.  Nonribosomal peptide synthetases and their biotechnological potential in Penicillium rubens.

Authors:  Riccardo Iacovelli; Roel A L Bovenberg; Arnold J M Driessen
Journal:  J Ind Microbiol Biotechnol       Date:  2021-08-24       Impact factor: 4.258
  8 in total

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