Literature DB >> 23726896

Autophagy proteins regulate cell engulfment mechanisms that participate in cancer.

Sung Eun Kim1, Michael Overholtzer.   

Abstract

Recent evidence has uncovered cross-regulation of mechanisms of cell engulfment by proteins of the autophagy pathway, in what is called LC3-Associated Phagocytosis, or LAP. By LAP, lysosome fusion to phagosomes and the degradation of engulfed extracellular cargo are facilitated by autophagy proteins that lipidate LC3 onto phagosome membranes. Here we discuss the contexts where LAP is known to occur by focusing on potential roles in tumorigenesis, including predicted consequences of LAP inhibition.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Autophagy; Cell death; Entosis; Immune; Macrophage; Phagocytosis; Tumor

Mesh：

Substances：

Year:  2013        PMID： 23726896      PMCID： PMC3791149          DOI： 10.1016/j.semcancer.2013.05.004

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  97 in total

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  10 in total

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8.  Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

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9.  An artificial lncRNA targeting multiple miRNAs overcomes sorafenib resistance in hepatocellular carcinoma cells.

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  10 in total

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