Literature DB >> 23726843

P97/CDC-48: proteostasis control in tumor cell biology.

Delphine Fessart1, Esther Marza, Saïd Taouji, Frédéric Delom, Eric Chevet.   

Abstract

P97/CDC-48 is a prominent member of a highly evolutionary conserved Walker cassette - containing AAA+ATPases. It has been involved in numerous cellular processes ranging from the control of protein homeostasis to membrane trafficking through the intervention of specific accessory proteins. Expression of p97/CDC-48 in cancers has been correlated with tumor aggressiveness and prognosis, however the precise underlying molecular mechanisms remain to be characterized. Moreover p97/CDC-48 inhibitors were developed and are currently under intense investigation as anticancer drugs. Herein, we discuss the role of p97/CDC-48 in cancer development and its therapeutic potential in tumor cell biology.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  CDC-48; Cancer; Proteostasis; VCP; p97

Mesh：

Substances：

Year:  2013        PMID： 23726843     DOI： 10.1016/j.canlet.2013.05.030

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  32 in total

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