| Literature DB >> 23726842 |
Ling Zhang1, Ruyi Shi, Chanting He, Caixia Cheng, Bin Song, Heyang Cui, Yanyan Zhang, Zhiping Zhao, Yanghui Bi, Xiaofeng Yang, Xiaoping Miao, Jiansheng Guo, Xing Chen, Jinfen Wang, Yaoping Li, Xiaolong Cheng, Jing Liu, Yongping Cui.
Abstract
Activating B-Raf mutations that deregulate the mitogen-activated protein kinase (MAPK) pathway commonly occur in cancer. Although B-Raf(V600E) induces increased Mps1 protein contributing to centrosome amplification and chromosome instability, the regulatory mechanisms of Mps1 in melanoma cells is not fully understood. Here, we report that Mps1/AKT and B-Raf(WT)/ERK signaling form an auto-regulatory negative feedback loop in melanoma cells; notably, oncogenic B-Raf(V600E) abrogates the negative feedback loop, contributing the aberrant Mps1 functions and tumorigenesis. Our findings raise the possibility that targeting the oncogenic B-Raf and Mps1, especially when used in combination could potentially provide great therapeutic opportunities for cancer treatment.Entities:
Keywords: AKT; B-Raf(V600E); B-Raf/ERK signaling; Melanoma; Mps1; Negative feedback
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Year: 2013 PMID： 23726842 DOI： 10.1016/j.canlet.2013.05.029
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679