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Literature DB >> 23726841

miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.

Ting-Hui Chu¹, Cheng-Chieh Yang, Chung-Ji Liu, Mann-Tin Lui, Shu-Chun Lin, Kuo-Wei Chang.

Abstract

miR-211 up-regulation and transforming growth factor-β type II receptor (TGFβRII) down-regulation are associated with poor prognosis of head and neck squamous cell carcinoma (HNSCC). miR-211 directly targets TGFβRII with the miR-211-TGFβRII-c-Myc axis promoting HNSCC progression. An inverse correlation of miR-211 and TGFβRII expression was found in metastatic HNSCC samples. After 4-nitroquinoline 1-oxide induction, more severe epithelial tumorigenesis was detected on K14-miR-211 transgenic mouse dorsal tongues. Human metastatic lesions and mouse tongue tumors showed increased nuclear c-Myc expression. A novel role for miR-211 in the regulation of TGFβRII and c-Myc during tumorigenesis being revealed should help to develop anti-HNSCC therapies.

Entities: Chemical Disease Gene Species

Keywords: Carcinoma; Head and neck; TGFβRII; Transgenic mouse; c-Myc; miR-211

Mesh：

Substances：

Year: 2013 PMID： 23726841 DOI： 10.1016/j.canlet.2013.05.032

Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679

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Cited

37 in total

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Authors: Leiguang Ye; Hui Wang; Baogang Liu
Journal: Tumour Biol Date: 2015-08-16

2. Transcriptome stability profiling using 5'-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells.

Authors: Piyush Joshi; Tatsuya Seki; Shinobu Kitamura; Andrea Bergano; Bongyong Lee; Ranjan J Perera
Journal: RNA Biol Date: 2019-06-16 Impact factor: 4.652

3. Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11.

Authors: Lei Wang; Yan-Feng Shen; Zhi-Min Shi; Xiao-Juan Shang; Dong-Ling Jin; Feng Xi
Journal: J Clin Lab Anal Date: 2017-07-13 Impact factor: 2.352

Review 4. Paradoxical roles of TGF-β signaling in suppressing and promoting squamous cell carcinoma.

Authors: Fanglong Wu; Kelsey J Weigel; Hongmei Zhou; Xiao-Jing Wang
Journal: Acta Biochim Biophys Sin (Shanghai) Date: 2018-01-01 Impact factor: 3.848

5. LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer.

Authors: Meihua Liang; Jinliang Jia; Lili Chen; Biyue Wei; Qiang Guan; Zhaoming Ding; Jiawei Yu; Rui Pang; Guoqing He
Journal: Endocrine Date: 2019-04-27 Impact factor: 3.633

6. Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages.

Authors: Ping-Hisen Chen; Chien-Hsien Wu; Yi-Fen Chen; Yi-Chen Yeh; Bo-Han Lin; Kuo-Wei Chang; Pei-Yu Lai; Ming-Chih Hou; Ching-Liang Lu; Wen-Chuan Kuo
Journal: Biomed Opt Express Date: 2018-03-02 Impact factor: 3.732

miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.

1. miR-211 promotes non-small cell lung cancer proliferation by targeting SRCIN1.

2. Transcriptome stability profiling using 5'-bromouridine IP chase (BRIC-seq) identifies novel and functional microRNA targets in human melanoma cells.

3. Overexpression miR-211-5p hinders the proliferation, migration, and invasion of thyroid tumor cells by downregulating SOX11.

Review 4. Paradoxical roles of TGF-β signaling in suppressing and promoting squamous cell carcinoma.

5. LncRNA MCM3AP-AS1 promotes proliferation and invasion through regulating miR-211-5p/SPARC axis in papillary thyroid cancer.

6. Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages.

7. MicroRNA-211 expression is down-regulated and associated with poor prognosis in human glioma.

8. MicroRNA 211 expression is upregulated and associated with poor prognosis in colorectal cancer: a case-control study.

9. MiR-106a-5p promotes 5-FU resistance and the metastasis of colorectal cancer by targeting TGFβR2.

10. MiR-211 inhibits cell proliferation and invasion of gastric cancer by down-regulating SOX4.