| Literature DB >> 2372660 |
Abstract
1. Inositol phospholipid hydrolysis was examined in human cerebral cortex slices by a [3H]-inositol prelabelling assay. 2. Enhancement of [3H]-inositol phosphates accumulation was observed in the presence of carbachol, noradrenaline, histamine, 5-hydroxytryptamine (5-HT) and depolarizing concentrations of KCl. 3. Despite having no effect alone, adenosine (and its analogue 2-chloroadenosine) selectively inhibited the direct response to histamine. 4. The inhibition due to adenosine was antagonized by theophylline, but not by 8-cyclopropyltheophylline.Entities:
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Year: 1990 PMID: 2372660 PMCID: PMC1917478 DOI: 10.1111/j.1476-5381.1990.tb12048.x
Source DB: PubMed Journal: Br J Pharmacol ISSN: 0007-1188 Impact factor: 8.739