PURPOSE: Our aims were to determine whether the pulse oximetric saturation/fraction of inspired oxygen (S/F) can be used for the early identification of patients with sepsis who are at increased risk for death and to compare the S/F ratio with the Pao2/fraction of inspired oxygen (P/F) ratio. MATERIALS AND METHODS: This is a retrospective cohort study in 260 patients admitted to 2 tertiary mixed intensive care units (ICUs) with severe sepsis or septic shock. We studied the association between tertiles of S/F ratio and ICU mortality using Cox regression. Subsequently, we compared corresponding measurements of S/F ratio and P/F ratio upon ICU admission using Pearson correlation coefficient (r). RESULTS: We observed an overall case fatality of 72 (28%) of 260. After adjustment for severity of the illness, the lowest tertile (S/F, <164) at ICU admission was associated with increased mortality (hazard ratio, 1.87 [95% confidence interval, 1.02-3.41]) comparing to the highest tertile (S/F, >236). The S/F ratio was correlated with P/F ratio (r=0.48; P<.0001). CONCLUSION: A low S/F at ICU admission is associated with increased risk of death in patients with severe sepsis or septic shock.
PURPOSE: Our aims were to determine whether the pulse oximetric saturation/fraction of inspired oxygen (S/F) can be used for the early identification of patients with sepsis who are at increased risk for death and to compare the S/F ratio with the Pao2/fraction of inspired oxygen (P/F) ratio. MATERIALS AND METHODS: This is a retrospective cohort study in 260 patients admitted to 2 tertiary mixed intensive care units (ICUs) with severe sepsis or septic shock. We studied the association between tertiles of S/F ratio and ICU mortality using Cox regression. Subsequently, we compared corresponding measurements of S/F ratio and P/F ratio upon ICU admission using Pearson correlation coefficient (r). RESULTS: We observed an overall case fatality of 72 (28%) of 260. After adjustment for severity of the illness, the lowest tertile (S/F, <164) at ICU admission was associated with increased mortality (hazard ratio, 1.87 [95% confidence interval, 1.02-3.41]) comparing to the highest tertile (S/F, >236). The S/F ratio was correlated with P/F ratio (r=0.48; P<.0001). CONCLUSION: A low S/F at ICU admission is associated with increased risk of death in patients with severe sepsis or septic shock.
Authors: Christos Skouras; Zoe A Davis; Joanne Sharkey; Rowan W Parks; O James Garden; John T Murchison; Damian J Mole Journal: HPB (Oxford) Date: 2015-11-18 Impact factor: 3.647
Authors: Eduardo Butturini de Carvalho; Thiago Ravache Sobreira Leite; Raquel Ferreira de Magalhães Sacramento; Paulo Roberto Loureiro do Nascimento; Cynthia Dos Santos Samary; Patrícia Rieken Macedo Rocco; Pedro Leme Silva Journal: Rev Bras Ter Intensiva Date: 2022 Jan-Mar