OBJECTIVES: A prospective surveillance study was conducted to investigate the epidemiology and patterns of antibiotic resistance among uropathogens from hospitalised children in Beira, Mozambique. Additionally, information regarding determinants of a urinary tract infection (UTI) was obtained. METHODS: Bacterial species identification, antimicrobial susceptibility testing and extended-spectrum beta-lactamase testing were performed for relevant bacterial isolates. RESULTS: Analysis of 170 urine samples from 148 children yielded 34 bacterial isolates, predominantly Escherichia coli and Klebsiella spp., causative of a urinary tract infection in 29 children; 30/34 isolates (88.2%) from 26/29 children (89.7%) were considered highly resistant micro-organisms (HRMOs). No significant determinants of urinary tract infection with HRMOs were detected when analysing gender, antibiotic use during hospital admission and HIV status. CONCLUSION: This study shows, for the first time in Mozambique, an extremely high prevalence of HRMOs among uropathogens from hospitalised children with a urinary tract infection.
OBJECTIVES: A prospective surveillance study was conducted to investigate the epidemiology and patterns of antibiotic resistance among uropathogens from hospitalised children in Beira, Mozambique. Additionally, information regarding determinants of a urinary tract infection (UTI) was obtained. METHODS: Bacterial species identification, antimicrobial susceptibility testing and extended-spectrum beta-lactamase testing were performed for relevant bacterial isolates. RESULTS: Analysis of 170 urine samples from 148 children yielded 34 bacterial isolates, predominantly Escherichia coli and Klebsiella spp., causative of a urinary tract infection in 29 children; 30/34 isolates (88.2%) from 26/29 children (89.7%) were considered highly resistant micro-organisms (HRMOs). No significant determinants of urinary tract infection with HRMOs were detected when analysing gender, antibiotic use during hospital admission and HIV status. CONCLUSION: This study shows, for the first time in Mozambique, an extremely high prevalence of HRMOs among uropathogens from hospitalised children with a urinary tract infection.
Authors: Troy D Moon; Wilson P Silva; Manuel Buene; Luís Morais; Emilio Valverde; Sten H Vermund; Paula E Brentlinger Journal: PLoS One Date: 2013-12-30 Impact factor: 3.240
Authors: Inocêncio Mate; Charlotte Elizabeth Come; Maria Patrícia Gonçalves; Julie Cliff; Eduardo Samo Gudo Journal: PLoS One Date: 2019-08-22 Impact factor: 3.240
Authors: Elisabet Guiral; Maria Jesús Pons; Delfino Vubil; Marta Marí-Almirall; Betuel Sigaúque; Sara Maria Soto; Pedro Luís Alonso; Joaquim Ruiz; Jordi Vila; Inácio Mandomando Journal: Infect Drug Resist Date: 2018-07-03 Impact factor: 4.003