BACKGROUND: The purpose of this study was to evaluate oncological and functional results of transoral laser microsurgery (TLM) in patients with T2 and T3 glottic laryngeal squamous cell carcinoma (SCC). METHODS: A retrospective chart analysis was carried out. Cases were classified into categories pT2a, pT2b, and pT3. Treatment was exclusively TLM ± selective neck dissection and adjuvant (chemo)radiotherapy. RESULTS: Three hundred ninety-one patients were treated by TLM; 142 cases were category pT2a, 127 were pT2b, and 122 were pT3. Median follow-up was 71 months. Five-year overall, recurrence-free, and disease specific survival rates were 72.2%, 76.4%, and 93.2% for pT2a tumors, 64.9%, 57.3%, and 83.9% for pT2b tumors, and 58.6%, 57.8%, and 84.1% for pT3 tumors, respectively. Larynx preservation was achieved in 93% (pT2a) and 83% (pT2b and pT3). CONCLUSION: Results are comparable to open partial or total laryngectomy and superior to primary (chemo)radiotherapy. TLM results in a lower morbidity and superior function compared to standard treatment.
BACKGROUND: The purpose of this study was to evaluate oncological and functional results of transoral laser microsurgery (TLM) in patients with T2 and T3 glottic laryngeal squamous cell carcinoma (SCC). METHODS: A retrospective chart analysis was carried out. Cases were classified into categories pT2a, pT2b, and pT3. Treatment was exclusively TLM ± selective neck dissection and adjuvant (chemo)radiotherapy. RESULTS: Three hundred ninety-one patients were treated by TLM; 142 cases were category pT2a, 127 were pT2b, and 122 were pT3. Median follow-up was 71 months. Five-year overall, recurrence-free, and disease specific survival rates were 72.2%, 76.4%, and 93.2% for pT2a tumors, 64.9%, 57.3%, and 83.9% for pT2b tumors, and 58.6%, 57.8%, and 84.1% for pT3tumors, respectively. Larynx preservation was achieved in 93% (pT2a) and 83% (pT2b and pT3). CONCLUSION: Results are comparable to open partial or total laryngectomy and superior to primary (chemo)radiotherapy. TLM results in a lower morbidity and superior function compared to standard treatment.
Authors: D De Seta; Flaminia Campo; V D'Aguanno; M Ralli; A Greco; F Y Russo; M de Vincentiis Journal: Lasers Med Sci Date: 2020-05-29 Impact factor: 3.161
Authors: Hendrik Andreas Wolff; Friedrich Ihler; Nina Zeller; Christian Welz; Klaus Jung; Martin Canis; Wolfgang Steiner Journal: Eur Arch Otorhinolaryngol Date: 2015-04-12 Impact factor: 2.503
Authors: Andy Trotti; Qiang Zhang; Søren M Bentzen; Bahman Emami; M Elizabeth Hammond; Christopher U Jones; William H Morrison; Stephen M Sagar; John A Ridge; Karen K Fu; K Kian Ang Journal: Int J Radiat Oncol Biol Phys Date: 2014-07-08 Impact factor: 7.038
Authors: Daniel Pedregal-Mallo; Mario Sánchez Canteli; Fernando López; César Álvarez-Marcos; José Luis Llorente; Juan Pablo Rodrigo Journal: Eur Arch Otorhinolaryngol Date: 2018-06-05 Impact factor: 2.503