BACKGROUND: Salivary duct carcinoma (SDC) is an aggressive malignancy with high recurrence rates. Standard management includes surgical resection followed by adjuvant radiation. Androgen receptor positivity has been described to be present in 40% to 90% of SDCs, and a recent case series showed a benefit to androgen deprivation therapy (ADT) in recurrent or metastatic disease. METHODS AND RESULTS: We present the case of an 87-year-old woman with a locally advanced androgen receptor-positive parotid SDC treated definitively with ADT and external beam radiotherapy, a regimen modeled after the treatment of prostate cancer. She had a complete response on positron emission tomography (PET)/CT scan and had no evidence of disease 24 months after the completion of treatment. CONCLUSION: To our knowledge, this case report is the first to describe the use of ADT plus radiation to definitively treat SDC. This regimen could be considered in patients with androgen receptor-positive SDCs who are considered unresectable or who refuse surgery.
BACKGROUND:Salivary duct carcinoma (SDC) is an aggressive malignancy with high recurrence rates. Standard management includes surgical resection followed by adjuvant radiation. Androgen receptor positivity has been described to be present in 40% to 90% of SDCs, and a recent case series showed a benefit to androgen deprivation therapy (ADT) in recurrent or metastatic disease. METHODS AND RESULTS: We present the case of an 87-year-old woman with a locally advanced androgen receptor-positive parotid SDC treated definitively with ADT and external beam radiotherapy, a regimen modeled after the treatment of prostate cancer. She had a complete response on positron emission tomography (PET)/CT scan and had no evidence of disease 24 months after the completion of treatment. CONCLUSION: To our knowledge, this case report is the first to describe the use of ADT plus radiation to definitively treat SDC. This regimen could be considered in patients with androgen receptor-positive SDCs who are considered unresectable or who refuse surgery.
Authors: Yang Ni; Francesco C Stingo; Min Jin Ha; Rehan Akbani; Veerabhadran Baladandayuthapani Journal: J Am Stat Assoc Date: 2018-08-15 Impact factor: 5.033
Authors: Ruta Gupta; Mark J Cowley; Simon A Mueller; Marie-Emilie A Gauthier; James Blackburn; John P Grady; Spiridoula Kraitsek; Elektra Hajdu; Matthias S Dettmer; Jane E Dahlstrom; C Soon Lee; Peter P Luk; Bing Yu; Roland Giger; Sarah Kummerfeld; Jonathan R Clark Journal: Mod Pathol Date: 2020-05-26 Impact factor: 7.842
Authors: Nhu Thuy Can; Mark W Lingen; Heather Mashek; James McElherne; Renee Briese; Carrie Fitzpatrick; Annemieke van Zante; Nicole A Cipriani Journal: Head Neck Pathol Date: 2017-07-05