Literature DB >> 23719021

Serotonin(2C) receptors in the ventral pallidum regulate motor function in rats.

Steven M Graves1, Annika A Viskniskki, Kathryn A Cunningham, T Celeste Napier.   

Abstract

The ventral pallidum is a limbic brain region that regulates motor function. This region is extensively innervated by serotoninergic neurons from the dorsal raphe nucleus. Serotonergic receptors, including the 5-HT(2C) receptor subtype, are located in the ventral pallidum. However, little is known regarding the behavioral consequences of serotonergic transmission in the ventral pallidum, and the role of 5-HT(2C) receptors has not been studied. To address this paucity, we measured the motoric consequences of injections of 0.33-10 ng of the 5-HT(2C) receptor agonist MK 212 into the ventral pallidum of adult male Sprague-Dawley rats. We determined that locomotor activity was attenuated by 6.6 ng MK 212, and rearing was attenuated by both 1 and 6.6 ng. The motor suppressant effects of MK 212 were lost at the higher dose of 10 ng, likely reflecting a loss of selectivity of this ligand. These findings indicate negative regulation of motor function by 5-HT(2C) receptors in the ventral pallidum.

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Year:  2013        PMID： 23719021      PMCID： PMC5708863          DOI： 10.1097/WNR.0b013e3283630af5

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  23 in total

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Journal:  Pharmacol Biochem Behav       Date:  2002-04       Impact factor: 3.533

5.  The neural substrates of amphetamine conditioned place preference: implications for the formation of conditioned stimulus-reward associations.

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Journal:  Eur J Neurosci       Date:  2006-10       Impact factor: 3.386

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  4 in total

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3.  Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule.

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4.  Activation of Ventral Tegmental Area 5-HT2C Receptors Reduces Incentive Motivation.

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  4 in total

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