Ibrahim A Abdelazim1, Hanan H Makhlouf. 1. Department of Obstetrics & Gynaecology, Ain Shams University, Cairo, Egypt. dr.ibrahimanwar@gmail.com
Abstract
AIM: This study was designed to compare the accuracy of placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) to diagnose premature rupture of fetal membranes (PROM). MATERIAL AND METHODS: This comparative prospective study was carried out over 3 years in Al-Rashid Maternity and Ahmadi Hospitals, Kuwait. One hundred and fifty pregnant women after 37 weeks gestation were included in this study for induction of labor and divided into two groups according to presence or absence of PROM. RESULTS: In this study, the sensitivity and specificity (97.3% and 98.7%) of PAMG-1 to diagnose PROM were statistically insignificant compared with the sensitivity and specificity (89.3% and 82.7%) of IGFBP-1. The PPV and NPV (98.6% and 97.4%) of PAMG-1 were also statistically insignificant compared with the PPV and NPV (83.8% and 88.6%) of IGFBP-1. Also, the accuracy (98%) of PAMG-1 was statistically insignificant compared with the accuracy (86%) of IGFBP-1 (P > 0.05). CONCLUSION: Although AmniSure test seems to be the most accurate test to diagnose rupture of the fetal membranes with high sensitivity and specificity, in this study the sensitivity, specificity and accuracy of AmniSure test to diagnose PROM were statistically insignificant compared with the sensitivity, specificity and accuracy of Actim PROM test.
AIM: This study was designed to compare the accuracy of placental alpha microglobulin-1 (PAMG-1) versus insulin-like growth factor binding protein-1 (IGFBP-1) to diagnose premature rupture of fetal membranes (PROM). MATERIAL AND METHODS: This comparative prospective study was carried out over 3 years in Al-Rashid Maternity and Ahmadi Hospitals, Kuwait. One hundred and fifty pregnant women after 37 weeks gestation were included in this study for induction of labor and divided into two groups according to presence or absence of PROM. RESULTS: In this study, the sensitivity and specificity (97.3% and 98.7%) of PAMG-1 to diagnose PROM were statistically insignificant compared with the sensitivity and specificity (89.3% and 82.7%) of IGFBP-1. The PPV and NPV (98.6% and 97.4%) of PAMG-1 were also statistically insignificant compared with the PPV and NPV (83.8% and 88.6%) of IGFBP-1. Also, the accuracy (98%) of PAMG-1 was statistically insignificant compared with the accuracy (86%) of IGFBP-1 (P > 0.05). CONCLUSION: Although AmniSure test seems to be the most accurate test to diagnose rupture of the fetal membranes with high sensitivity and specificity, in this study the sensitivity, specificity and accuracy of AmniSure test to diagnose PROM were statistically insignificant compared with the sensitivity, specificity and accuracy of Actim PROM test.
Authors: George U Eleje; Euzebus C Ezugwu; Ifeanyichukwu U Ezebialu; Nnabuike O Ojiegbe; Richard O Egeonu; Chukwudi C Obiora; Chigozie G Okafor; Joseph I Ikechebelu; Ahizechukwu C Eke Journal: Int J Gynaecol Obstet Date: 2018-11-20 Impact factor: 4.447