Kanok Hournkumnuard1, Mayuree Natenapit. 1. Department of Physics, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand.
Abstract
PURPOSE: The targeting of ferromagnetic drug carrier nanoparticles (DCNPs) by dilute microferromagnetic wires implanted within blood vessels and subjected to an externally applied uniform magnetic field of 0.1-0.8 T was evaluated to determine their effectiveness in increasing the concentration of the DCNPs around the target wires. METHODS: The transport of DCNPs under the influences of diffusion, blood convection, and magnetic force was simulated by solving the continuity equation using the finite difference method. Then the spatial distribution and time evolution of the particle concentration was determined. The effectiveness of implant-assisted magnetic drug targeting was evaluated from the average concentration of DCNPs around the representative target wire. RESULTS: The average concentration of DCNPs of an average radius larger than 80 nm carried by blood flow with an average inlet flow rate of 1.1 cm s(-1) was increased to more than 60% of the injected concentration by using an externally applied magnetic field strength of 0.1 T. CONCLUSIONS: The effectiveness of concentrating DCNPs of an average radius not larger than 100 nm around the target wire within a small vein was significantly improved using an externally applied magnetic field strength of not greater than 0.8 T.
PURPOSE: The targeting of ferromagnetic drug carrier nanoparticles (DCNPs) by dilute microferromagnetic wires implanted within blood vessels and subjected to an externally applied uniform magnetic field of 0.1-0.8 T was evaluated to determine their effectiveness in increasing the concentration of the DCNPs around the target wires. METHODS: The transport of DCNPs under the influences of diffusion, blood convection, and magnetic force was simulated by solving the continuity equation using the finite difference method. Then the spatial distribution and time evolution of the particle concentration was determined. The effectiveness of implant-assisted magnetic drug targeting was evaluated from the average concentration of DCNPs around the representative target wire. RESULTS: The average concentration of DCNPs of an average radius larger than 80 nm carried by blood flow with an average inlet flow rate of 1.1 cm s(-1) was increased to more than 60% of the injected concentration by using an externally applied magnetic field strength of 0.1 T. CONCLUSIONS: The effectiveness of concentrating DCNPs of an average radius not larger than 100 nm around the target wire within a small vein was significantly improved using an externally applied magnetic field strength of not greater than 0.8 T.
Authors: Beatriz Pelaz; Christoph Alexiou; Ramon A Alvarez-Puebla; Frauke Alves; Anne M Andrews; Sumaira Ashraf; Lajos P Balogh; Laura Ballerini; Alessandra Bestetti; Cornelia Brendel; Susanna Bosi; Monica Carril; Warren C W Chan; Chunying Chen; Xiaodong Chen; Xiaoyuan Chen; Zhen Cheng; Daxiang Cui; Jianzhong Du; Christian Dullin; Alberto Escudero; Neus Feliu; Mingyuan Gao; Michael George; Yury Gogotsi; Arnold Grünweller; Zhongwei Gu; Naomi J Halas; Norbert Hampp; Roland K Hartmann; Mark C Hersam; Patrick Hunziker; Ji Jian; Xingyu Jiang; Philipp Jungebluth; Pranav Kadhiresan; Kazunori Kataoka; Ali Khademhosseini; Jindřich Kopeček; Nicholas A Kotov; Harald F Krug; Dong Soo Lee; Claus-Michael Lehr; Kam W Leong; Xing-Jie Liang; Mei Ling Lim; Luis M Liz-Marzán; Xiaowei Ma; Paolo Macchiarini; Huan Meng; Helmuth Möhwald; Paul Mulvaney; Andre E Nel; Shuming Nie; Peter Nordlander; Teruo Okano; Jose Oliveira; Tai Hyun Park; Reginald M Penner; Maurizio Prato; Victor Puntes; Vincent M Rotello; Amila Samarakoon; Raymond E Schaak; Youqing Shen; Sebastian Sjöqvist; Andre G Skirtach; Mahmoud G Soliman; Molly M Stevens; Hsing-Wen Sung; Ben Zhong Tang; Rainer Tietze; Buddhisha N Udugama; J Scott VanEpps; Tanja Weil; Paul S Weiss; Itamar Willner; Yuzhou Wu; Lily Yang; Zhao Yue; Qian Zhang; Qiang Zhang; Xian-En Zhang; Yuliang Zhao; Xin Zhou; Wolfgang J Parak Journal: ACS Nano Date: 2017-03-14 Impact factor: 15.881