Sir,We read with interest the article by Singh et al.[1] reporting a comparative study of the effects of granisetron, magnesium sulfate, and nitroglycerine for the reduction of propofol injection pain. The authors report that all three drugs reduced the incidence and intensity of propofol injection pain compared to the control solution (0.9% normal saline) with the order of effectiveness being granisetron > nitroglycerin > magnesium sulfate > control. We agree with the authors statistical findings when testing amongst all groups is performed at each of the study time points following propofol injection (i.e., 5, 10, 15, and 20 seconds). However, when pairwise tests are performed using either the authors’ reported method (Chi-square test) or the more appropriate Fisher's exact test, given the relatively small number of study subjects per group, the differences in the incidence of propofol injection pain for subjects receiving magnesium sulfate compared to normal saline fail to reach statistical significance at any of the time points [Table 1]. In this regard, we disagree with the authors’ conclusion suggesting that magnesium sulfate pretreatment reduces the incidence of propofol injection pain. It would be beneficial for readers to have the authors address this issue or provide further details regarding their statistical analyses.