Literature DB >> 23716994

Expression of huCdc7 in colorectal cancer.

Hai-Jun Chen1, Zhen Zhu, Xue-Lin Wang, Quan-Lin Feng, Qing Wu, Zheng-Ping Xu, Jiang Wu, Xiao-Feng Yu, Hong-Liang Qian, Qi Lu.   

Abstract

AIM: To detect the expression of huCdc7 in colorectal cancer.
METHODS: The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively.
RESULTS: The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues (0.03675 ± 1.00 vs 0.01199 ± 0.44, P < 0.05). huCdc7-positive cells displayed brown granules in the nucleus. Tumor tissues contained many huCdc7-positive cells, whereas normal colorectal tissues contained very few positive cells.
CONCLUSION: huCdc7 may play an important role in the development and progression of colorectal cancer.

Entities:  

Keywords:  Colorectal cancer; Semiquantitative reverse transcription-polymerase chain reaction; huCdc7

Mesh：

Substances：

Year:  2013        PMID： 23716994      PMCID： PMC3662954          DOI： 10.3748/wjg.v19.i20.3130

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  10 in total

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7.  Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells.

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8.  Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma.

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10.  Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation.

Authors:  Dorine Bonte; Charlotta Lindvall; Hongyu Liu; Karl Dykema; Kyle Furge; Michael Weinreich
Journal:  Neoplasia       Date:  2008-09       Impact factor: 5.715
  10 in total
  4 in total

1.  Cdc7 overexpression is an independent prognostic marker and a potential therapeutic target in colorectal cancer.

Authors:  Nathaniel Melling; Johanna Muth; Ronald Simon; Carsten Bokemeyer; Luigi Terracciano; Guido Sauter; Jakob Robert Izbicki; Andreas Holger Marx
Journal:  Diagn Pathol       Date:  2015-07-25       Impact factor: 2.644

2.  The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds.

Authors:  Nanda Kumar Sasi; Kanchan Tiwari; Fen-Fen Soon; Dorine Bonte; Tong Wang; Karsten Melcher; H Eric Xu; Michael Weinreich
Journal:  PLoS One       Date:  2014-11-20       Impact factor: 3.240

3.  DDK Promotes Tumor Chemoresistance and Survival via Multiple Pathways.

Authors:  Nanda Kumar Sasi; Arjun Bhutkar; Nathan J Lanning; Jeffrey P MacKeigan; Michael Weinreich
Journal:  Neoplasia       Date:  2017-04-25       Impact factor: 5.715

4.  Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation.

Authors:  Zohreh Jaafari-Ashkavandi; Mohammad Javad Ashraf; Ali Asghar Abbaspoorfard
Journal:  Braz J Otorhinolaryngol       Date:  2017-12-26
  4 in total

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