OBJECTIVES: The purpose of this study was to evaluate the renal volume and intrarenal hemodynamics with duplex sonography in a group of diabetic patients with normal renal function in comparison to nondiabetic controls. METHODS: The renal volume and resistive index (RI) of segmental arteries were assessed by duplex sonography in 88 diabetic patients (44 male and 44 female; median age, 58 years [range, 37-69 years]) and 73 nondiabetic control participants (48 male and 25 female; median age, 53 years [range, 27-75 years]) without renal artery stenosis. RESULTS: Both renal volume and RI values in the diabetic patients were significantly higher compared to the controls (mean volume ± SD: diabetic patients, 197.3 ± 47.6 mL; controls, 162.5 ± 35.2 mL; P < .0001; RI: diabetic patients, 0.70 ± 0.05; controls, 0.59 ± 0.06; P < .0001). Renal hypertrophy was present even in diabetic patients without proteinuria (renal volume: patients without proteinuria, 198.3 ± 45.9 mL; controls, 162.5 ± 35.2 mL; P < .005). Patients with higher RI values had significantly greater proteinuria (RI <0.75, 15.9 mg/g [range, 4.2-1718.9 mg/g]; RI >0.75, 37.9 mg/g [range, 11.34-2087.0 mg/g]; P < .02). CONCLUSIONS: Changes in renal volume and hemodynamics are detectable on sonography in diabetic patients. Those changes are also present in patients without proteinuria or signs of renal atherosclerosis and with both normal and increased glomerular filtration rates. These results indicate a potential role of duplex sonography in the early identification of morphologic and hemodynamic renal changes in type 2 diabetic patients.
OBJECTIVES: The purpose of this study was to evaluate the renal volume and intrarenal hemodynamics with duplex sonography in a group of diabeticpatients with normal renal function in comparison to nondiabetic controls. METHODS: The renal volume and resistive index (RI) of segmental arteries were assessed by duplex sonography in 88 diabeticpatients (44 male and 44 female; median age, 58 years [range, 37-69 years]) and 73 nondiabetic control participants (48 male and 25 female; median age, 53 years [range, 27-75 years]) without renal artery stenosis. RESULTS: Both renal volume and RI values in the diabeticpatients were significantly higher compared to the controls (mean volume ± SD: diabeticpatients, 197.3 ± 47.6 mL; controls, 162.5 ± 35.2 mL; P < .0001; RI: diabeticpatients, 0.70 ± 0.05; controls, 0.59 ± 0.06; P < .0001). Renal hypertrophy was present even in diabeticpatients without proteinuria (renal volume: patients without proteinuria, 198.3 ± 45.9 mL; controls, 162.5 ± 35.2 mL; P < .005). Patients with higher RI values had significantly greater proteinuria (RI <0.75, 15.9 mg/g [range, 4.2-1718.9 mg/g]; RI >0.75, 37.9 mg/g [range, 11.34-2087.0 mg/g]; P < .02). CONCLUSIONS: Changes in renal volume and hemodynamics are detectable on sonography in diabeticpatients. Those changes are also present in patients without proteinuria or signs of renal atherosclerosis and with both normal and increased glomerular filtration rates. These results indicate a potential role of duplex sonography in the early identification of morphologic and hemodynamic renal changes in type 2 diabeticpatients.
Entities:
Keywords:
diabetes; diabetic nephropathy; proteinuria; renal hypertrophy; resistive index
Authors: Riccardo Pofi; Daniela Fiore; Rita De Gaetano; Giuseppe Panio; Daniele Gianfrilli; Carlotta Pozza; Federica Barbagallo; Yang Kevin Xiang; Konstantinos Giannakakis; Susanna Morano; Andrea Lenzi; Fabio Naro; Andrea M Isidori; Mary Anna Venneri Journal: Sci Rep Date: 2017-03-15 Impact factor: 4.379
Authors: Kim M Gooding; Chrysta Lienczewski; Massimo Papale; Niina Koivuviita; Marlena Maziarz; Anna-Maria Dutius Andersson; Kanishka Sharma; Paola Pontrelli; Alberto Garcia Hernandez; Julie Bailey; Kay Tobin; Virva Saunavaara; Anna Zetterqvist; David Shelley; Irvin Teh; Claire Ball; Sapna Puppala; Mark Ibberson; Anil Karihaloo; Kaj Metsärinne; Rosamonde E Banks; Peter S Gilmour; Michael Mansfield; Mark Gilchrist; Dick de Zeeuw; Hiddo J L Heerspink; Pirjo Nuutila; Matthias Kretzler; Matthew Welberry Smith; Loreto Gesualdo; Dennis Andress; Nicolas Grenier; Angela C Shore; Maria F Gomez; Steven Sourbron Journal: BMC Nephrol Date: 2020-06-29 Impact factor: 2.388