| Literature DB >> 23715951 |
Meer Tarique Ali1, Ritesh Fule, Ajay Sav, Purnima Amin.
Abstract
To circumvent the solubility-related issues associated with Biopharmaceutics Classification System class II drugs, a novel porous carrier has been developed. In the present study, a process for preparation of porous starch (PS) is demonstrated. The process briefly comprises of translucent gel preparation followed by solvent replacement, drying, and sizing. Carbamazepine (CBZ) was used as a drug candidate to exhibit solubility enhancement potential of PS. PS and CBZ-loaded PS (CBZ-PS) systems were characterized with respect to IR, DSC, XRD, SEM, and dissolution kinetic studies. PS-CBZ was found to follow a Fickian behavior during dissolution. In vivo studies conducted in mice displayed a superior performance of CBZ-PS as compared to neat CBZ.Entities:
Mesh：
Substances：
Year: 2013 PMID： 23715951 PMCID： PMC3755161 DOI： 10.1208/s12249-013-9985-6
Source DB: PubMed Journal: AAPS PharmSciTech ISSN： 1530-9932 Impact factor: 3.246