Literature DB >> 23715834

Early treatment causes clinicoradiological reversal of myelopathy due to vitamin B12 deficiency.

Rajesh Verma1, Prakash Kori, Tushar B Patil, Heramba Narayan Praharaj.   

Abstract

Vitamin B12 deficiency has a wide spectrum of clinical presentation with a variety of neurological symptoms and signs. As a result, many patients lack classic features of advanced severe deficiency. Early diagnosis and treatment are crucial in order to prevent the irreversible damage to the nervous system. We describe a 25-year-old man, who presented with predominant sensory symptoms without any signs on clinical evaluation. His serum vitamin B12 levels were low and neuroimaging revealed myelopathy. The patient was treated promptly with cyanocobalamin injections, which lead to a rapid resolution of symptoms and radiological abnormalities.

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Year:  2013        PMID: 23715834      PMCID: PMC3669956          DOI: 10.1136/bcr-2013-009090

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  8 in total

1.  A case of subacute combined degeneration: MRI findings.

Authors:  K Yamada; D A Shrier; H Tanaka; Y Numaguchi
Journal:  Neuroradiology       Date:  1998-06       Impact factor: 2.804

2.  Case report: MR appearances in vitamin B12 neuropathy.

Authors:  V W Ng; M Gross; A Clifton
Journal:  Clin Radiol       Date:  1997-05       Impact factor: 2.350

3.  MRI demonstration of reversible impairment of the blood-CNS barrier function in subacute combined degeneration of the spinal cord.

Authors:  W Küker; V Hesselmann; A Thron; A de Simone
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-03       Impact factor: 10.154

4.  MRI appearances in subacute combined degeneration of the spinal cord due to vitamin B12 deficiency.

Authors:  A J Larner; A Z Zeman; C M Allen; N M Antoun
Journal:  J Neurol Neurosurg Psychiatry       Date:  1997-01       Impact factor: 10.154

5.  MRI in vitamin B12 deficiency myelopathy.

Authors:  E R Locatelli; R Laureno; P Ballard; A S Mark
Journal:  Can J Neurol Sci       Date:  1999-02       Impact factor: 2.104

6.  Spinal MRI in progressive myeloneuropathy associated with vitamin E deficiency.

Authors:  M Vorgerd; M Tegenthoff; D Kühne; J P Malin
Journal:  Neuroradiology       Date:  1996-05       Impact factor: 2.804

Review 7.  Neurological complications of acquired cobalamin deficiency: clinical aspects.

Authors:  D G Savage; J Lindenbaum
Journal:  Baillieres Clin Haematol       Date:  1995-09

8.  Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study.

Authors:  Zahit Bolaman; Gurhan Kadikoylu; Vahit Yukselen; Irfan Yavasoglu; Sabri Barutca; Taskin Senturk
Journal:  Clin Ther       Date:  2003-12       Impact factor: 3.393

  8 in total
  2 in total

1.  Neuroregression as an initial manifestation in a toddler with acquired pernicious anaemia.

Authors:  Sangeetha Yoganathan; Maya Mary Thomas; Sarah Mathai; Urmi Ghosh
Journal:  BMJ Case Rep       Date:  2015-12-17

2.  A Tale of Treatable Infantile Neuroregression and Diagnostic Dilemma with Glutaric Aciduria Type I.

Authors:  Sangeetha Yoganathan; Mugil Varman; Samuel Philip Oommen; Maya Thomas
Journal:  J Pediatr Neurosci       Date:  2017 Oct-Dec
  2 in total

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