Literature DB >> 23715090

Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase.

Nicolaos Avlonitis1, Manuelle Debunne, Tashfeen Aslam, Neil McDonald, Chris Haslett, Kevin Dhaliwal, Mark Bradley.   

Abstract

Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases.

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Year:  2013        PMID： 23715090     DOI： 10.1039/c3ob40212f

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Development of an alveolar transbronchial catheter for concurrent fiber optics based imaging and fluid delivery.

Authors:  Nathan Knighton; Brian Cottle; Veronique Dentan; Tom Vercauteren; Ahsan Akram; Annya Bruce; Kevin Dhaliwal; Robert Hitchcock
Journal:  J Med Device       Date:  2018-07-24       Impact factor: 0.582

2.  A BODIPY-Tagged Phosphono Peptide as Activity-Based Probe for Human Leukocyte Elastase.

Authors:  Anna-Christina Schulz-Fincke; Michael Blaut; Annett Braune; Michael Gütschow
Journal:  ACS Med Chem Lett       Date:  2018-03-04       Impact factor: 4.345

Review 3.  Activatable Fluorophores for Imaging Immune Cell Function.

Authors:  Lorena Mendive-Tapia; Marc Vendrell
Journal:  Acc Chem Res       Date:  2022-04-05       Impact factor: 24.466

4.  Separating the isomers--efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B.

Authors:  Aurélie Brunet; Tashfeen Aslam; Mark Bradley
Journal:  Bioorg Med Chem Lett       Date:  2014-05-04       Impact factor: 2.823

5.  Activated neutrophil fluorescent imaging technique for human lungs.

Authors:  Thomas H Craven; Tashfeen Walton; Ahsan R Akram; Emma Scholefield; Neil McDonald; Adam D L Marshall; Duncan C Humphries; Bethany Mills; Thane A Campbell; Annya Bruce; Joanne Mair; James W Dear; David E Newby; Adam T Hill; Timothy S Walsh; Chris Haslett; Kevin Dhaliwal
Journal:  Sci Rep       Date:  2021-01-13       Impact factor: 4.379

6.  Super-silent FRET Sensor Enables Live Cell Imaging and Flow Cytometric Stratification of Intracellular Serine Protease Activity in Neutrophils.

Authors:  Thomas H Craven; Nicolaos Avlonitis; Neil McDonald; Tashfeen Walton; Emma Scholefield; Ahsan R Akram; Timothy S Walsh; Chris Haslett; Mark Bradley; Kevin Dhaliwal
Journal:  Sci Rep       Date:  2018-09-10       Impact factor: 4.379
  6 in total

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