| Literature DB >> 23715038 |
Junji Inokoshi1, Naoki Shigeta, Takashi Fukuda, Ryuji Uchida, Kenichi Nonaka, Rokurou Masuma, Hiroshi Tomoda.
Abstract
A new compound, designated epi-trichosetin (1), was isolated along with the known compound trichosetin (2) from the culture broth of Fusarium oxysporum FKI-4553 by solvent extraction, silica gel column chromatography and reversed-phase HPLC. The structure of 1 was elucidated by comparing various spectral data with those of 2, revealing that 1 was a stereoisomer of 2. Compounds 1 and 2 inhibited the undecaprenyl pyrophosphate synthase activity of Staphylococcus aureus with IC50 values of 83 and 30 μM, respectively, and showed antimicrobial activity, particularly against Gram-positive bacteria, including methicillin-sensitive and -resistant S. aureus.Entities:
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Year: 2013 PMID： 23715038 DOI： 10.1038/ja.2013.44
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649