BACKGROUND: The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for stroke patients with a prior history of coronary artery disease (CAD). METHODS: We enrolled 148 acute ischemic stroke patients (mean age, 74.2 years; males, 77.0%) with a history of CAD. Pre-admission CHADS2 scores were calculated by assigning a single point for the presence of congestive heart failure, hypertension, age ≥75 years, and diabetes; and assigning 2 points for a prior history of stroke or transient ischemic attack. Comparisons were made between patients with poor and good 3-month functional outcomes. A multivariate logistic regression analysis was performed to assess the predictive value of CHADS2 scores for poor outcome. RESULTS: The patients with poor and good outcomes displayed significant differences in CHADS2 scores (median, 3 vs. 2, P=0.014), carotid artery stenosis (41.0% vs. 24.6%, P=0.037), intracranial artery stenosis (32.5% vs. 15.4%, P=0.017), atrial fibrillation (31.3% vs. 16.9%, P=0.045), and admission NIHSS score (median, 11 vs. 5, P<0.001). The CHADS2 score was an independent determinant of poor functional outcome on a multivariate analysis (per 1 point increase: OR 1.47, 95% CI 1.05-2.11, P=0.025; CHADS2 score ≥3: OR 1.58, 95% CI 1.01-2.54, P=0.050). CONCLUSIONS: The CHADS2 score is a potential useful tool for predicting functional outcome in stroke patients with a history of CAD.
BACKGROUND: The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for strokepatients with a prior history of coronary artery disease (CAD). METHODS: We enrolled 148 acute ischemic strokepatients (mean age, 74.2 years; males, 77.0%) with a history of CAD. Pre-admission CHADS2 scores were calculated by assigning a single point for the presence of congestive heart failure, hypertension, age ≥75 years, and diabetes; and assigning 2 points for a prior history of stroke or transient ischemic attack. Comparisons were made between patients with poor and good 3-month functional outcomes. A multivariate logistic regression analysis was performed to assess the predictive value of CHADS2 scores for poor outcome. RESULTS: The patients with poor and good outcomes displayed significant differences in CHADS2 scores (median, 3 vs. 2, P=0.014), carotid artery stenosis (41.0% vs. 24.6%, P=0.037), intracranial artery stenosis (32.5% vs. 15.4%, P=0.017), atrial fibrillation (31.3% vs. 16.9%, P=0.045), and admission NIHSS score (median, 11 vs. 5, P<0.001). The CHADS2 score was an independent determinant of poor functional outcome on a multivariate analysis (per 1 point increase: OR 1.47, 95% CI 1.05-2.11, P=0.025; CHADS2 score ≥3: OR 1.58, 95% CI 1.01-2.54, P=0.050). CONCLUSIONS: The CHADS2 score is a potential useful tool for predicting functional outcome in strokepatients with a history of CAD.
Authors: Benjamin Adam Steinberg; Phillip Joel Schulte; Paul Hofmann; Mads Ersbøll; John Hunter Alexander; Kathleen Broderick-Forsgren; Kevin Joseph Anstrom; Christopher Bull Granger; Jonathan Paul Piccini; Eric Jose Velazquez; Bimal Ramesh Shah Journal: Am J Cardiol Date: 2015-02-18 Impact factor: 2.778