Literature DB >> 23712423

[Randomized controlled trials terminated prematurely: beneficial therapy effects].

L A Kluth1, M Rink, S A Ahyai, M Fisch, S F Shariat, P Dahm.   

Abstract

Randomized controlled trials (RCTs) stopped prematurely for beneficial therapy effects are becoming increasingly more prevalent in the urological literature and often receive great attention in the public and medical media. Urologists who practice evidence-based medicine should be aware of the potential bias and the different reasons why and how early termination of RCTs can and will affect the results. This review provides insights into the challenges clinical urologists face by interpreting the results of prematurely terminated RCTs.

Mesh:

Year:  2013        PMID: 23712423     DOI: 10.1007/s00120-013-3144-2

Source DB:  PubMed          Journal:  Urologe A        ISSN: 0340-2592            Impact factor:   0.639


  9 in total

1.  Intensive insulin therapy in critically ill patients.

Authors:  G van den Berghe; P Wouters; F Weekers; C Verwaest; F Bruyninckx; M Schetz; D Vlasselaers; P Ferdinande; P Lauwers; R Bouillon
Journal:  N Engl J Med       Date:  2001-11-08       Impact factor: 91.245

Review 2.  Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis.

Authors:  Dirk Bassler; Matthias Briel; Victor M Montori; Melanie Lane; Paul Glasziou; Qi Zhou; Diane Heels-Ansdell; Stephen D Walter; Gordon H Guyatt; David N Flynn; Mohamed B Elamin; Mohammad Hassan Murad; Nisrin O Abu Elnour; Julianna F Lampropulos; Amit Sood; Rebecca J Mullan; Patricia J Erwin; Clare R Bankhead; Rafael Perera; Carolina Ruiz Culebro; John J You; Sohail M Mulla; Jagdeep Kaur; Kara A Nerenberg; Holger Schünemann; Deborah J Cook; Kristina Lutz; Christine M Ribic; Noah Vale; German Malaga; Elie A Akl; Ignacio Ferreira-Gonzalez; Pablo Alonso-Coello; Gerard Urrutia; Regina Kunz; Heiner C Bucher; Alain J Nordmann; Heike Raatz; Suzana Alves da Silva; Fabio Tuche; Brigitte Strahm; Benjamin Djulbegovic; Neill K J Adhikari; Edward J Mills; Femida Gwadry-Sridhar; Haresh Kirpalani; Heloisa P Soares; Paul J Karanicolas; Karen E A Burns; Per Olav Vandvik; Fernando Coto-Yglesias; Pedro Paulo M Chrispim; Tim Ramsay
Journal:  JAMA       Date:  2010-03-24       Impact factor: 56.272

3.  GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables.

Authors:  Gordon Guyatt; Andrew D Oxman; Elie A Akl; Regina Kunz; Gunn Vist; Jan Brozek; Susan Norris; Yngve Falck-Ytter; Paul Glasziou; Hans DeBeer; Roman Jaeschke; David Rind; Joerg Meerpohl; Philipp Dahm; Holger J Schünemann
Journal:  J Clin Epidemiol       Date:  2010-12-31       Impact factor: 6.437

Review 4.  Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer.

Authors:  Gerhardt Attard; Arie S Belldegrun; Johann S de Bono
Journal:  BJU Int       Date:  2005-12       Impact factor: 5.588

Review 5.  Randomized trials stopped early for benefit: a systematic review.

Authors:  Victor M Montori; P J Devereaux; Neill K J Adhikari; Karen E A Burns; Christoph H Eggert; Matthias Briel; Christina Lacchetti; Teresa W Leung; Elizabeth Darling; Dianne M Bryant; Heiner C Bucher; Holger J Schünemann; Maureen O Meade; Deborah J Cook; Patricia J Erwin; Amit Sood; Richa Sood; Benjamin Lo; Carly A Thompson; Qi Zhou; Edward Mills; Gordon H Guyatt
Journal:  JAMA       Date:  2005-11-02       Impact factor: 56.272

6.  Evidence-based urology in practice: incorporating patient values in evidence-based clinical decision making.

Authors:  Steven E Canfield; Philipp Dahm
Journal:  BJU Int       Date:  2009-10-10       Impact factor: 5.588

7.  Abiraterone and increased survival in metastatic prostate cancer.

Authors:  Johann S de Bono; Christopher J Logothetis; Arturo Molina; Karim Fizazi; Scott North; Luis Chu; Kim N Chi; Robert J Jones; Oscar B Goodman; Fred Saad; John N Staffurth; Paul Mainwaring; Stephen Harland; Thomas W Flaig; Thomas E Hutson; Tina Cheng; Helen Patterson; John D Hainsworth; Charles J Ryan; Cora N Sternberg; Susan L Ellard; Aude Fléchon; Mansoor Saleh; Mark Scholz; Eleni Efstathiou; Andrea Zivi; Diletta Bianchini; Yohann Loriot; Nicole Chieffo; Thian Kheoh; Christopher M Haqq; Howard I Scher
Journal:  N Engl J Med       Date:  2011-05-26       Impact factor: 91.245

8.  The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group.

Authors:  D Poldermans; E Boersma; J J Bax; I R Thomson; L L van de Ven; J D Blankensteijn; H F Baars; T I Yo; G Trocino; C Vigna; J R Roelandt; H van Urk
Journal:  N Engl J Med       Date:  1999-12-09       Impact factor: 91.245

9.  Designs for group sequential tests.

Authors:  T R Fleming; D P Harrington; P C O'Brien
Journal:  Control Clin Trials       Date:  1984-12
  9 in total

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